Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 6/20 | 0.72 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.57 |
| ▸ | SQSTM1 | Q13501 | 2/20 | 0.57 |
| ▸ | ACLY | P53396 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.54 |
| ▸ | TUBB | P07437 | 1/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.54 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.54 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.54 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.54 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.54 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540814 | 0.91 | KEAP1 (0.68) | STAT3KEAP1NFE2L2SQSTM1MITF | |
| SCHEMBL22234983 | 0.91 | KEAP1 (0.68) | STAT3KEAP1NFE2L2SQSTM1MITF | |
| SCHEMBL28347360 | 0.88 | STAT3 (0.77) | STAT3KEAP1NFE2L2SQSTM1ACLY | |
| SCHEMBL29540501 | 0.88 | KEAP1 (0.67) | STAT3KEAP1NFE2L2SQSTM1TUBB4A | |
| SCHEMBL29540848 | 0.81 | KEAP1 (0.54) | STAT3KEAP1NFE2L2SQSTM1MITF | |
| SCHEMBL22233905 | 0.81 | KEAP1 (0.54) | STAT3KEAP1NFE2L2SQSTM1MITF | |
| SCHEMBL29892350 | 0.78 | KEAP1 (0.83) | STAT3KEAP1NFE2L2SQSTM1MITF | |
| SCHEMBL26089402 | 0.75 | KEAP1 (1.00) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL29892935 | 0.74 | KEAP1 (0.81) | STAT3KEAP1NFE2L2SQSTM1MITF | |
| SCHEMBL28410068 | 0.74 | STAT3 (0.69) | STAT3KEAP1NFE2L2SQSTM1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12122742-B2 | Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-10-22 | — | — | US | disclosed |
| US-20220112160-A1 | SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112160-A1 | SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | KEAP1, NFE2L2, HMOX1 | STAT3 220/4885KEAP1 1/4885NFE2L2 2/4885 |
| US-12122742-B2 | Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction | KEAP1, NFE2L2, HMOX1 | STAT3 220/4885KEAP1 1/4885NFE2L2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.