Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29544495 | 0.86 | GSK3B (0.35) | GSK3BDYRK1ATGFBR1AAK1IRAK4 | |
| SCHEMBL29544745 | 0.84 | TYK2 (0.36) | RIPK3TGFBR1IRAK4CDK9RORC | |
| SCHEMBL29544758 | 0.82 | EGFR (0.39) | RIPK3TGFBR1CDK9RORCEGFR | |
| SCHEMBL29545167 | 0.79 | PIK3CA (0.32) | GSK3BTGFBR1PIK3CAMTOR | |
| SCHEMBL29544451 | 0.76 | BUB1 (0.33) | — | |
| SCHEMBL29544631 | 0.76 | TGFBR1 (0.46) | RIPK3GSK3BDYRK1ATGFBR1AAK1 | |
| SCHEMBL29545042 | 0.74 | PIM1 (0.36) | CDK9EGFRSRCKDR | |
| SCHEMBL29545041 | 0.74 | PIM1 (0.36) | CDK9EGFRSRCKDR | |
| SCHEMBL29544561 | 0.73 | MET (0.34) | TGFBR1PIK3CAMTOR | |
| SCHEMBL29544753 | 0.73 | CCNC (0.36) | DYRK1ATGFBR1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022072634-A1 | BICYCLIC COMPOUNDS FOR USE IN THE TREATMENT CANCER | SCORPION THERAPEUTICS, INC. (US) | 2022-04-07 | — | — | WO | disclosed |