SCHEMBL2956112

SCHEMBL2956112

COC(=O)c1c(C)nn(C)c1Cl

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.55
LMNA P02545 1/20 0.50
ALDH1A1 P00352 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.44
KDM4E B2RXH2 6/20 0.43
HPGD P15428 2/20 0.42
MAPT P10636 1/20 0.41
TSHR P16473 2/20 0.40
HSD17B10 Q99714 2/20 0.40
GLA P06280 1/20 0.40
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP3A4 P08684 1/20 0.39
RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8371895 0.83 L3MBTL1 (0.45) L3MBTL1LMNAALDH1A1SMN1; SMN2KDM4E
SCHEMBL2963689 0.82 L3MBTL1 (0.53) L3MBTL1LMNAALDH1A1SMN1; SMN2KDM4E
SCHEMBL759605 0.79 L3MBTL1 (0.56) L3MBTL1LMNAALDH1A1SMN1; SMN2KDM4E
SCHEMBL8261357 0.79 L3MBTL1 (0.56) L3MBTL1LMNAALDH1A1SMN1; SMN2KDM4E
SCHEMBL1335837 0.79 L3MBTL1 (0.60) L3MBTL1LMNAALDH1A1SMN1; SMN2KDM4E
SCHEMBL10576705 0.78 HPGD (0.56) L3MBTL1LMNAALDH1A1KDM4EHPGD
SCHEMBL840603 0.78 L3MBTL1 (0.43) L3MBTL1LMNAALDH1A1KDM4EHPGD
SCHEMBL10576114 0.77 HPGD (0.39) L3MBTL1LMNAALDH1A1SMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL8760435 0.77 L3MBTL1 (0.58) L3MBTL1LMNAALDH1A1SMN1; SMN2KDM4E
SCHEMBL13343071 0.77 L3MBTL1 (0.54) L3MBTL1LMNAALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103613583-A 1, 3-substituent-4-substituted pyrazol acylhydrazone derivative and preparation method and application thereof UNIV GUIZHOU 2014-03-05 CN claimed
CN-103613583-B 1,3-substituting group-4-substituted pyrazolecarboxylic acylhydrazone and its preparation method and application GUIZHOU UNIVERSITY (CN) 2015-12-02 CN disclosed
CN-103613583-A 1, 3-substituent-4-substituted pyrazol acylhydrazone derivative and preparation method and application thereof UNIV GUIZHOU 2014-03-05 CN disclosed
US-7759291-B2 Pyrazole compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-07-20 US disclosed
US-7759291-B2 Pyrazole compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-07-20 US disclosed
EP-1711471-B1 PYRAZOLE COMPOUNDS AND USE THEREOF IN NOXIOUS ARTHROPOD PESTS CONTROLLING COMPOSITION SUMITOMO CHEMICAL CO (JP) 2010-03-24 EP disclosed
US-20090192208-A1 Pyrazole compounds and use thereof in noxious arthropod pests controlling composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-30 US disclosed
US-20090192208-A1 Pyrazole compounds and use thereof in noxious arthropod pests controlling composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-30 US disclosed
CN-1176918-C Alpha-substituted benzene acetic acid its preparation and farm pesticide containing said compound ��Ұ����ҩ��ʽ���� 2004-11-24 CN disclosed
CN-1105703-C Alpha-substituted phenylacetic acid derivatives, their preparation and agricultural fungicides containing the same SHIONOGI & CO (JP) 2003-04-16 CN disclosed
CN-1394846-A Alpha-substituted benzene acetic acid its preparation and farm pesticide containing said compound SHIONOGI & CO (JP) 2003-02-05 CN disclosed
US-6313150-B1 FOR CONTROLLING PHYTOPATHOGENIC FUNGI SHIONOGI & CO., LTD. (JP) 2001-11-06 US disclosed
EP-0754672-B1 GAMMA-SUBSTITUTED PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL BACTERICIDE CONTAINING THE SAME SHIONOGI & CO (JP) 2000-10-11 EP disclosed
US-5948819-A α-substituted phenylacetic acid derivative, its production and agricultural fungicide containing it SHIONOGI & CO., LTD (JP) 1999-09-07 US disclosed
CN-1145061-A Alpha-substituted phenylacetic acid derivatives, their preparation and agricultural fungicides containing the same SHIONOGI & CO (JP) 1997-03-12 CN disclosed
EP-0754672-A1 GAMMA-SUBSTITUTED PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL BACTERICIDE CONTAINING THE SAME SHIONOGI & CO., LTD. (JP) 1997-01-22 EP disclosed
US-4872901-A PREFERENTIAL TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-10-10 US disclosed
EP-0220695-A1 Herbicidal compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1987-05-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090192208-A1 Pyrazole compounds and use thereof in noxious arthropod pests controlling composition TRPA1, ACHE, MORF4L1 L3MBTL1 313/4885LMNA 4386/4885ALDH1A1 2171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.