SCHEMBL29583388

SCHEMBL29583388

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C

nearest known ligand 0.61

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 12/20 0.61
▸ NPBWR1 P48145 3/20 0.58
▸ KEAP1 Q14145 1/20 0.56
▸ KISS1R Q969F8 1/20 0.55
▸ PCSK9 Q8NBP7 2/20 0.55
▸ RXFP1 Q9HBX9 1/20 0.55
▸ ECE1 P42892 1/20 0.55
▸ MUS81 Q96NY9 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30633324 0.94 NPBWR1 (0.64) GLP1RNPBWR1RXFP1
SCHEMBL10537009 0.88 MAGI3 (0.61) GLP1RNPBWR1PCSK9RXFP1ECE1
SCHEMBL31467396 0.88 KISS1R (0.62) GLP1RNPBWR1KISS1RPCSK9
SCHEMBL29983511 0.88 GLP1R (0.62) GLP1RKEAP1RXFP1ECE1MUS81
SCHEMBL31099263 0.87 GLP1R (0.63) GLP1RNPBWR1RXFP1ECE1MUS81
SCHEMBL29634675 0.87 GLP1R (0.63) GLP1RNPBWR1RXFP1ECE1MUS81
SCHEMBL30906492 0.86 GLP1R (0.70) GLP1RRXFP1ECE1MUS81
SCHEMBL31087271 0.86 RXFP1 (0.68) GLP1RNPBWR1RXFP1ECE1MUS81
SCHEMBL30271994 0.86 RXFP1 (0.68) GLP1RNPBWR1RXFP1ECE1MUS81
SCHEMBL31759108 0.86 RXFP1 (0.67) GLP1RNPBWR1KEAP1RXFP1ECE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12428447-B2 Peptide-based non-proteinaceous cargo delivery FELDAN BIO INC. (CA) 2025-09-30 — — US disclosed
EP-4556567-A2 RATIONALLY-DESIGNED SYNTHETIC PEPTIDE SHUTTLE AGENTS FOR DELIVERING POLYPEPTIDE CARGOS FROM AN EXTRACELLULAR SPACE TO THE CYTOSOL AND/OR NUCLEUS OF A TARGET EUKARYOTIC CELL, USES THEREOF, METHODS AND KITS RELATING TO SAME Feldan Bio Inc. (CA) 2025-05-21 — — EP disclosed
US-12286632-B2 Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same FELDAN BIO INC. (CA) 2025-04-29 — — US disclosed
US-12144910-B2 Methods of coating antimicrobial peptides on the biomaterial and the biomaterial coated thereby ACADEMIA SINICA (TW) 2024-11-19 — — US disclosed
US-12060387-B2 Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same FELDAN BIO INC. (CA) 2024-08-13 — — US disclosed
US-20230399661-A1 SHUTTLE AGENT PEPTIDES OF MINIMAL LENGTH AND VARIANTS THEREOF ADAPTED FOR TRANSDUCTION OF CAS9-RNP AND OTHER NUCLEOPROTEIN CARGOS FELDAN BIO INC. (CA) 2023-12-14 — — US disclosed
US-20230383291-A1 PEPTIDE-BASED TRANSDUCTION OF NON-ANIONIC POLYNUCLEOTIDE ANALOGS FOR GENE EXPRESSION MODULATION FELDAN BIO INC. (CA) 2023-11-30 — — US disclosed
US-20230348537-A1 RATIONALLY-DESIGNED SYNTHETIC PEPTIDE SHUTTLE AGENTS FOR DELIVERING POLYPEPTIDE CARGOS FROM AN EXTRACELLULAR SPACE TO THE CYTOSOL AND/OR NUCLEUS OF A TARGET EUKARYOTIC CELL, USES THEREOF, METHODS AND KITS RELATING TO SAME FELDAN BIO INC. (CA) 2023-11-02 — — US disclosed
EP-4232590-A1 SHUTTLE AGENT PEPTIDES OF MINIMAL LENGTH AND VARIANTS THEREOF ADAPTED FOR TRANSDUCTION OF CAS9-RNP AND OTHER NUCLEOPROTEIN CARGOS Feldan Bio Inc. (CA) 2023-08-30 — — EP disclosed
EP-4229207-A1 PEPTIDE-BASED TRANSDUCTION OF NON-ANIONIC POLYNUCLEOTIDE ANALOGS FOR GENE EXPRESSION MODULATION Feldan Bio Inc. (CA) 2023-08-23 — — EP disclosed
US-11629170-B2 Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same FELDAN BIO INC. (CA) 2023-04-18 — — US disclosed
US-20220226545-A1 METHODS OF COATING ANTIMICROBIAL PEPTIDES ON THE BIOMATERIAL AND THE BIOMATERIAL COATED THEREBY ACADEMIA SINICA (TW) 2022-07-21 — — US disclosed
US-20220204561-A1 PEPTIDE-BASED NON-PROTEINACEOUS CARGO DELIVERY FELDAN BIO INC. (CA) 2022-06-30 — — US disclosed
WO-2022082315-A1 SHUTTLE AGENT PEPTIDES OF MINIMAL LENGH AND VARIANTS THEREOF ADAPTED FOR TRANSDUCTION OF CAS9-RNP AND OTHER NUCLEOPROTEIN CARGOS FELDAN BIO INC. (CA) 2022-04-28 — — WO disclosed
WO-2022077121-A1 PEPTIDE-BASED TRANSDUCTION OF NON-ANIONIC POLYNUCLEOTIDE ANALOGS FOR GENE EXPRESSION MODULATION FELDAN BIO INC. (CA) 2022-04-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12286632-B2 Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same KPNA6, KPNA1, KPNA2 GLP1R 3100/4885NPBWR1 1857/4885KEAP1 1516/4885
US-11629170-B2 Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same KPNA6, KPNA1, KPNA2 GLP1R 3100/4885NPBWR1 1857/4885KEAP1 1516/4885
US-20230348537-A1 RATIONALLY-DESIGNED SYNTHETIC PEPTIDE SHUTTLE AGENTS FOR DELIVERING POLYPEPTIDE CARGOS FROM AN EXTRACELLULAR SPACE TO THE CYTOSOL AND/OR NUCLEUS OF A TARGET EUKARYOTIC CELL, USES THEREOF, METHODS AND KITS RELATING TO SAME KPNA6, KPNA1, KPNA2 GLP1R 3100/4885NPBWR1 1857/4885KEAP1 1516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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