Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5276864 | 1.00 | MEN1 (0.48) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL981676 | 0.84 | LMNA (0.55) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL4944634 | 0.81 | THRB (0.52) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL29134977 | 0.79 | MEN1 (0.41) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL7763133 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1TDP1LMNA | |
| Naphthalene SCHEMBL10495715 | 0.77 | TDP1 (0.55) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL11690201 | 0.77 | TYMS (0.44) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL29620230 | 0.75 | TSHR (0.53) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL29620231 | 0.75 | TSHR (0.53) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL4103602 | 0.75 | TSHR (0.53) | MEN1KMT2AALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081655-A1 | SUBSTITUTED DIHYDROPYRANOPYRIMIDINE COMPOUNDS AS KRAS INHIBITORS | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2022-04-21 | — | — | WO | disclosed |