Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21544698 | 0.81 | NAAA (0.50) | KMT2ANAAALMNASMN1; SMN2HSD11B1 | |
| SCHEMBL30888343 | 0.80 | NAAA (0.47) | NAAALMNASMN1; SMN2HSD11B1OPRM1 | |
| SCHEMBL25387067 | 0.80 | NAAA (0.52) | NAAALMNASMN1; SMN2HSD11B1CES2 | |
| SCHEMBL29572719 | 0.77 | HTT (0.43) | MEN1KMT2ALMNAMAOA | |
| SCHEMBL18043699 | 0.76 | CA1 (0.55) | NAAAOPRM1OPRL1MAOBMAOA | |
| SCHEMBL22027030 | 0.74 | NAAA (0.44) | KMT2ANAAALMNASMN1; SMN2HSD11B1 | |
| SCHEMBL22026919 | 0.73 | NAAA (0.46) | NAAALMNASMN1; SMN2HSD11B1CYP3A4 | |
| SCHEMBL22362684 | 0.71 | LMNA (0.48) | KMT2ANAAALMNASMN1; SMN2HSD11B1 | |
| SCHEMBL11047671 | 0.71 | F10 (0.48) | KMT2ASMN1; SMN2OPRM1OPRL1CYP3A4 | |
| SCHEMBL22027090 | 0.71 | NAAA (0.47) | KMT2ANAAALMNASMN1; SMN2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450283-B | 3, 6-Diamino-pyridazin-3-yl derivatives, pharmaceutical compositions containing them and their use as pro-apoptotic agents | 法国施维雅药厂 | 2024-05-07 | — | — | CN | disclosed |
| CN-114450283-A | 3, 6-diamino-pyridazin-3-yl derivatives, pharmaceutical compositions containing them and their use as pro-apoptotic agents | 法国施维雅药厂 | 2022-05-06 | — | — | CN | disclosed |