Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9162336 | 0.77 | ALDH1A1 (0.83) | ALDH1A1SMN1; SMN2TSHRACHEKDM4E | |
| SCHEMBL2781893 | 0.76 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2NPSR1ACHEKDM4E | |
| SCHEMBL9168254 | 0.75 | ACHE (0.64) | ALDH1A1SMN1; SMN2TSHRACHEKDM4E | |
| SCHEMBL1472784 | 0.74 | MAPK1 (0.53) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL19813835 | 0.73 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL16995098 | 0.72 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2ACHEKDM4EHSD17B10 | |
| SCHEMBL2781199 | 0.71 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPK1ACHEKDM4E | |
| SCHEMBL2781822 | 0.71 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2TSHRACHEKDM4E | |
| SCHEMBL2779689 | 0.71 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2NPSR1ACHEKDM4E | |
| SCHEMBL24994428 | 0.70 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2TSHRACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767812-B2 | Crystals of pyrimidine compound and process for producing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-7767812-B2 | Crystals of pyrimidine compound and process for producing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-7767812-B2 | Crystals of pyrimidine compound and process for producing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| EP-2210889-A1 | Process for producing pyrimidine compound | Eisai R&D Management Co., Ltd. (JP) | 2010-07-28 | — | — | EP | disclosed |
| EP-2210889-A1 | Process for producing pyrimidine compound | Eisai R&D Management Co., Ltd. (JP) | 2010-07-28 | — | — | EP | disclosed |
| US-20100179321-A1 | SALT OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-07-15 | — | — | US | disclosed |
| US-20100179321-A1 | SALT OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-07-15 | — | — | US | disclosed |
| US-20100179321-A1 | SALT OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-07-15 | — | — | US | disclosed |
| US-7538117-B2 | Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-7538117-B2 | Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-7396928-B2 | Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-07-08 | — | — | US | disclosed |
| US-7396928-B2 | Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-07-08 | — | — | US | disclosed |
| EP-1862463-A1 | PYRIMIDINE COMPOUND CRYSTAL OR AMORPHOUS FORM AND PROCESS FOR PRODUCING THE SAME | Eisai R&D Management Co., Ltd. (JP) | 2007-12-05 | — | — | EP | disclosed |
| EP-1862463-A1 | PYRIMIDINE COMPOUND CRYSTAL OR AMORPHOUS FORM AND PROCESS FOR PRODUCING THE SAME | Eisai R&D Management Co., Ltd. (JP) | 2007-12-05 | — | — | EP | disclosed |
| EP-1840128-A1 | CRYSTAL OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1- METHYLPYRIDIN-2(1H)-ONE AND PROCESS FOR PRODUCING THE SAME | Eisai R&D Management Co., Ltd. (JP) | 2007-10-03 | — | — | EP | disclosed |
| EP-1840128-A1 | CRYSTAL OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1- METHYLPYRIDIN-2(1H)-ONE AND PROCESS FOR PRODUCING THE SAME | Eisai R&D Management Co., Ltd. (JP) | 2007-10-03 | — | — | EP | disclosed |
| US-20070078151-A1 | Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds | EISAI CO., LTD. (JP) | 2007-04-05 | — | — | US | disclosed |
| US-20070078151-A1 | Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds | EISAI CO., LTD. (JP) | 2007-04-05 | — | — | US | disclosed |
| US-20070078151-A1 | Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds | EISAI CO., LTD. (JP) | 2007-04-05 | — | — | US | disclosed |
| US-20060235225-A1 | Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same | EISAI CO., LTD. (JP) | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179321-A1 | SALT OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND CRYSTAL THEREOF | SLC28A1, SLC28A2, SLC20A1 | ALDH1A1 684/4885SMN1; SMN2 2540/4885TSHR 4011/4885 |
| US-20070078151-A1 | Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds | UMPS, TYMP, UPP1 | ALDH1A1 2704/4885SMN1; SMN2 613/4885TSHR 4293/4885 |
| US-20060235225-A1 | Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same | APC, MLN, CROCC | ALDH1A1 2131/4885SMN1; SMN2 80/4885TSHR 4480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.