Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LYPLA1 | O75608 | 1/20 | 0.45 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | AGXT | P21549 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29614620 | 0.85 | TSHR (0.44) | TSHRLYPLA1LYPLA2KDM4EMEN1 | |
| SCHEMBL9013795 | 0.82 | CYP1A2 (0.46) | TSHRKDM4EMEN1TRPM2ALDH1A1 | |
| SCHEMBL1554914 | 0.76 | TSHR (0.73) | TSHRLYPLA1LYPLA2KDM4EMEN1 | |
| SCHEMBL2400633 | 0.73 | TRPV6 (0.58) | TSHRLYPLA1LYPLA2KDM4EPOLB | |
| SCHEMBL9795394 | 0.71 | TSHR (0.94) | TSHRKDM4ETACR1IDO1AGXT | |
| SCHEMBL2399799 | 0.70 | LYPLA1 (0.55) | TSHRLYPLA1LYPLA2KDM4EMEN1 | |
| SCHEMBL178228 | 0.69 | TSHR (0.62) | TSHRLYPLA1LYPLA2KDM4EPOLB | |
| SCHEMBL12266167 | 0.69 | TSHR (0.61) | TSHRLYPLA1LYPLA2KDM4EMEN1 | |
| SCHEMBL5311581 | 0.68 | TSHR (1.00) | TSHRKDM4EALDH1A1CYP1A2TACR1 | |
| SCHEMBL27380 | 0.68 | TSHR (1.00) | TSHRKDM4EALDH1A1CYP1A2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12544371-B2 | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | CALCIMEDICA, INC. (US) | 2026-02-10 | — | — | US | disclosed |
| US-20250120969-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | AVENUE CAPITAL MANAGEMENT II, L.P. | 2025-04-17 | — | — | US | disclosed |
| EP-4465988-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | Calcimedica, Inc. (US) | 2024-11-27 | — | — | EP | disclosed |
| CN-118871110-A | Methods and compositions for treating inflammatory lesions of the lung | 钙医学公司 | 2024-10-29 | — | — | CN | disclosed |
| US-12036241-B2 | Compositions and methods for immune cell modulation in adoptive immunotherapies | FATE THERAPEUTICS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| EP-3989979-B1 | CAPACITATIVE CALCIUM ENTRY INHIBITORS | UNIV PARIS SACLAY (FR) | 2024-06-12 | — | — | EP | disclosed |
| WO-2023141523-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | CALCIMEDICA, INC. (US) | 2023-07-27 | — | — | WO | disclosed |
| US-20230120819-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | AVENUE CAPITAL MANAGEMENT II, L.P. | 2023-04-20 | — | — | US | disclosed |
| CN-115835878-A | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | 钙医学公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4121089-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | Calcimedica, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| US-20220362267-A1 | CAPACITATIVE CALCIUM ENTRY INHIBITORS | Sorbonne Université (FR) | 2022-11-17 | — | — | US | disclosed |
| EP-3989979-A1 | CAPACITATIVE CALCIUM ENTRY INHIBITORS | Université Paris-Saclay (FR) | 2022-05-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12544371-B2 | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | ORAI1, MAVS, CASR | TSHR 3502/4885LYPLA1 3217/4885LYPLA2 2604/4885 |
| US-20250120969-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | IL1B, MAVS, MMP8 | TSHR 4488/4885LYPLA1 3160/4885LYPLA2 2751/4885 |
| US-20230120819-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | MAVS, ATF1, IL1B | TSHR 4369/4885LYPLA1 3196/4885LYPLA2 2822/4885 |
| US-20220362267-A1 | CAPACITATIVE CALCIUM ENTRY INHIBITORS | ORAI1, SARAF, ORAI2 | TSHR 2854/4885LYPLA1 3000/4885LYPLA2 2724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.