Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 4/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP4 | P49662 | 1/20 | 0.46 |
| ▸ | CASP5 | P51878 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29615692 | 1.00 | TRPV6 (0.62) | TRPV6CHRNB2CHRNA4ALDH1A1MAPT | |
| SCHEMBL31329931 | 0.84 | TRPV6 (0.80) | TRPV6CHRNB2CHRNA4ALDH1A1KDM4E | |
| SCHEMBL23225374 | 0.83 | ALDH1A1 (0.58) | TRPV6ALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL21216229 | 0.83 | ALDH1A1 (0.58) | TRPV6ALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL28283653 | 0.82 | CHRNB2 (0.71) | TRPV6CHRNB2CHRNA4ALDH1A1MAPT | |
| SCHEMBL29615833 | 0.81 | TRPV6 (0.54) | TRPV6CHRNB2CHRNA4ALDH1A1MAPT | |
| SCHEMBL938061 | 0.79 | CHRNB2 (0.61) | TRPV6CHRNB2CHRNA4ALDH1A1MAPT | |
| SCHEMBL5091037 | 0.79 | SIGMAR1 (0.54) | TRPV6ALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL12250 | 0.78 | CHRNB2 (0.65) | TRPV6CHRNB2CHRNA4ALDH1A1MAPT | |
| SCHEMBL12449679 | 0.78 | CHRNB2 (0.65) | TRPV6CHRNB2CHRNA4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11351170-B2 | Substituted pyrimidines as CDK4/6 inhibitors | BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) | 2022-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11351170-B2 | Substituted pyrimidines as CDK4/6 inhibitors | CDK4, CDK6, CDK2 | TRPV6 3973/4885CHRNB2 3875/4885CHRNA4 3227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.