Sugi Predict

Sugi Predict / Compounds / SCHEMBL29617263

SCHEMBL29617263

SCHEMBL29617263

O=C1c2ccccc2C(=O)N1[C@H](C(O)O)C12CC3CC(CC(C3)C1)C2.[Rh].[Rh]

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 1/20 0.39
▸ TSHR P16473 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ ALDH1A1 P00352 3/20 0.35
▸ HTT P42858 1/20 0.35
▸ GAA P10253 2/20 0.34
▸ FPR1 P21462 1/20 0.34
▸ CNR2 P34972 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ EPHX1 P07099 1/20 0.34
▸ P2RX7 Q99572 1/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.33
▸ IDO1 P14902 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ GLA P06280 1/20 0.33
▸ POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14175420 0.98 EPHX2 (0.40) EPHX2TSHRLMNAALDH1A1HTT
SCHEMBL14175279 0.98 EPHX2 (0.40) EPHX2TSHRLMNAALDH1A1HTT
SCHEMBL14175421 0.86 ERCC1 (0.43) LMNAALDH1A1HTTGAACYP1A2
SCHEMBL14175050 0.86 ERCC1 (0.43) LMNAALDH1A1HTTGAACYP1A2
SCHEMBL14175048 0.86 ERCC1 (0.43) LMNAALDH1A1HTTGAACYP1A2
SCHEMBL31756476 0.78 ALDH1A1 (0.42) EPHX2TSHRLMNAALDH1A1HTT
SCHEMBL4951371 0.77 MEN1 (0.40) EPHX2TSHRLMNAALDH1A1HTT
SCHEMBL4946433 0.77 ALDH1A1 (0.43) EPHX2TSHRLMNAALDH1A1HTT
SCHEMBL4951450 0.77 ALDH1A1 (0.43) EPHX2TSHRLMNAALDH1A1HTT
SCHEMBL14648459 0.75 EPHX2 (0.41) EPHX2TSHRLMNAALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431421-A Compound with axial chirality or boron chirality BODIPYs and preparation method and application thereof 中国医学科学院药用植物研究所 2025-02-14 — — CN claimed
CN-116425760-B Synthesis method of chiral (-) -cephalotaxine, intermediate and analogue thereof 兰州大学 2024-11-26 — — CN claimed
CN-116789594-A Synthesis method of N-alkylated pyridine-2-ketone derivative 常州大学 2023-09-22 — — CN claimed
CN-116768777-A Method for constructing nitrogen-nitrogen axis chiral dipyrrole compound with high stereoselectivity 常州大学 2023-09-19 — — CN claimed
CN-114605302-B Method for synthesizing carbon-carbon axis chiral indole-naphthol biaryl compound by using chiral rhodium catalysis 常州大学 2023-07-25 — — CN claimed
CN-116425760-A Synthesis method of chiral (-) -cephalotaxine, intermediate and analogue thereof 兰州大学 2023-07-14 — — CN claimed
CN-114605302-A Method for synthesizing carbon-carbon axis chiral indole-naphthol biaryl compound by using chiral rhodium as catalyst 常州大学 2022-06-10 — — CN claimed
CN-114560802-A Method for constructing carbon-nitrogen axis chiral indole-naphthol biaryl compound 常州大学 2022-05-31 — — CN claimed
US-12582719-B2 Chimeric compounds and methods of managing neurological disorders or conditions EMORY UNIVERSITY (US) 2026-03-24 — — US disclosed
US-20260001877-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED (US) 2026-01-01 — — US disclosed
CN-119431421-A Compound with axial chirality or boron chirality BODIPYs and preparation method and application thereof 中国医学科学院药用植物研究所 2025-02-14 — — CN disclosed
CN-116425760-B Synthesis method of chiral (-) -cephalotaxine, intermediate and analogue thereof 兰州大学 2024-11-26 — — CN disclosed
CN-113185553-B Chiral phosphoric acid compound with aryl indole carbazole skeleton, and preparation method and application thereof 王磊 2024-07-26 — — CN disclosed
CN-116789594-A Synthesis method of N-alkylated pyridine-2-ketone derivative 常州大学 2023-09-22 — — CN disclosed
CN-114605302-B Method for synthesizing carbon-carbon axis chiral indole-naphthol biaryl compound by using chiral rhodium catalysis 常州大学 2023-07-25 — — CN disclosed
CN-116425760-A Synthesis method of chiral (-) -cephalotaxine, intermediate and analogue thereof 兰州大学 2023-07-14 — — CN disclosed
CN-112920149-B Chiral dihydropyran ring derivative and preparation method and application thereof 中山大学 2022-12-02 — — CN disclosed
CN-114605302-A Method for synthesizing carbon-carbon axis chiral indole-naphthol biaryl compound by using chiral rhodium as catalyst 常州大学 2022-06-10 — — CN disclosed
CN-114560802-A Method for constructing carbon-nitrogen axis chiral indole-naphthol biaryl compound 常州大学 2022-05-31 — — CN disclosed
US-20220133892-A1 Chimeric Compounds and Methods of Managing Neurological Disorders or Conditions UNIV EMORY (US) 2022-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001877-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN CNR1, SCN1B, OPRL1 EPHX2 804/4885TSHR 575/4885LMNA 1409/4885
US-20220133892-A1 Chimeric Compounds and Methods of Managing Neurological Disorders or Conditions MAOA, HNMT, HDAC6 EPHX2 713/4885TSHR 1974/4885LMNA 813/4885
US-12582719-B2 Chimeric compounds and methods of managing neurological disorders or conditions SLC6A4, HTR4, HTR1A EPHX2 2116/4885TSHR 206/4885LMNA 3752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.