SCHEMBL29623910

SCHEMBL29623910

Nc1nc(Cl)nc2ccc(Br)cc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 1.00
ADRB2 P07550 1/20 0.54
BCHE P06276 5/20 0.47
ACHE P22303 5/20 0.47
GRIN1 Q05586 5/20 0.47
GRIN2A Q12879 5/20 0.47
NT5E P21589 1/20 0.47
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
BACE1 P56817 2/20 0.43
PDPK1 O15530 1/20 0.42
JAK2 O60674 1/20 0.42
PABPC1 P11940 1/20 0.42
GAA P10253 1/20 0.41
KMT2A Q03164 1/20 0.41
ADORA2A P29274 1/20 0.41
MPO P05164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8897424 1.00 HTT (1.00) HTTADRB2BCHEACHEGRIN1
SCHEMBL29663118 0.85 HTT (0.74) HTTADRB2BCHEACHEGRIN1
SCHEMBL19876615 0.85 HTT (0.74) HTTADRB2BCHEACHEGRIN1
SCHEMBL29441517 0.81 HTT (0.68) HTTBCHEACHEGRIN1GRIN2A
SCHEMBL4358438 0.81 HTT (0.68) HTTADRB2PABPC1ADORA2A
SCHEMBL21500731 0.81 HTT (0.68) HTTBCHEACHEGRIN1GRIN2A
SCHEMBL182719 0.81 HTT (0.68) HTTBCHEACHEGRIN1GRIN2A
SCHEMBL29649743 0.81 HTT (0.68) HTTADRB2PABPC1ADORA2A
SCHEMBL30973214 0.79 HTT (0.65) HTTADRB2BCHEACHEGRIN1
SCHEMBL3778992 0.78 HTT (0.64) HTTBCHEACHEGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-221123533-U Capacitive cooling liquid level sensor 奥卡冷却系统(天津)有限公司 2024-06-11 CN claimed
US-12534730-B2 Compositions and methods for inhibiting GYS2 expression NOVO NORDISK A/S (DK) 2026-01-27 US disclosed
US-20250270075-A1 SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING BUILDING MATERIAL OBJECTS STRUCTURAL SERVICES INC (US) 2025-08-28 US disclosed
EP-4567112-A1 RNA INHIBITOR FOR INHIBITING APOC3 GENE EXPRESSION AND USE THEREOF Kylonova (Xiamen) Biopharma Co., Ltd. (CN) 2025-06-11 EP disclosed
CN-111901919-B Phase-cut dimming input signal detection circuit and method 赛尔富电子有限公司 2025-05-16 CN disclosed
US-20250145424-A1 SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING BUILDING MATERIAL OBJECTS STRUCTURAL SERVICES INC (US) 2025-05-08 US disclosed
US-12195306-B2 Systems and methods for identifying and locating building material objects STRUCTURAL SERVICES, INC. (US) 2025-01-14 US disclosed
CN-114825939-B High-precision switching power supply circuit based on double-group output of single transformer 冠捷电子科技(福建)有限公司 2024-10-22 CN disclosed
WO-2024172819-A1 SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING BUILDING MATERIAL OBJECTS STRUCTURAL SERVICES, INC. (US) 2024-08-22 WO disclosed
CN-221531069-U Photovoltaic arrester monitor 南京法欧电气有限公司 2024-08-13 CN disclosed
CN-111819779-B Power supply LG伊诺特有限公司 2023-06-23 CN disclosed
CN-112369124-B Light source driving device and method thereof LG伊诺特有限公司 2023-06-06 CN disclosed
US-11661603-B2 Compositions and methods for inhibiting ALDH2 expression DICERNA PHARMACEUTICALS, INC. (US) 2023-05-30 US disclosed
US-11572562-B2 Compositions and methods for inhibiting GYS2 expression DICERNA PHARMACEUTICALS, INC. (US) 2023-02-07 US disclosed
CN-217741368-U CC signal circuit of alternating current charging gun 四川永贵科技有限公司 2022-11-04 CN disclosed
CN-114825939-A High-precision switching power supply circuit based on double-group output of single transformer 冠捷电子科技(福建)有限公司 2022-07-29 CN disclosed
CN-114448227-B Photovoltaic inverter system and regulating circuit thereof 浙江日风电气股份有限公司 2022-07-08 CN disclosed
US-20220186229-A1 METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF CYP27A1 DICERNA PHARMACEUTICALS, INC. 2022-06-16 US disclosed
US-20220170025-A1 COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION IN THE CENTRAL NERVOUS SYSTEM NOVO NORDISK A/S (DK) 2022-06-02 US disclosed
CN-114448227-A Photovoltaic inverter system and regulating circuit thereof 浙江日风电气股份有限公司 2022-05-06 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572562-B2 Compositions and methods for inhibiting GYS2 expression GYS2, GYS1, GLS2 HTT 2714/4885ADRB2 4675/4885BCHE 4434/4885
US-12534730-B2 Compositions and methods for inhibiting GYS2 expression GYS2, GYS1, GLS2 HTT 3267/4885ADRB2 4223/4885BCHE 4581/4885
US-20220186229-A1 METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF CYP27A1 RNASE1, CYP7B1, CYP27A1 HTT 4592/4885ADRB2 3292/4885BCHE 1815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.