Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963146 | 1.00 | KDM4E (0.50) | KDM4EJUNNFKB1NPC1MAPT | |
| SCHEMBL14682667 | 0.87 | KDM4E (0.48) | KDM4EJUNNFKB1NPC1MAPT | |
| SCHEMBL24668281 | 0.82 | MAPT (0.43) | KDM4EJUNNFKB1NPC1MAPT | |
| SCHEMBL10846493 | 0.79 | KDM4E (0.64) | KDM4EMAPTMEN1KMT2AENPP2 | |
| SCHEMBL3144474 | 0.79 | KDM4E (0.64) | KDM4EMAPTMEN1KMT2AENPP2 | |
| Pyridine SCHEMBL27556477 | 0.77 | NFE2L2 (0.47) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6332022 | 0.76 | JUN (0.50) | KDM4EJUNNFKB1NPC1MAPT | |
| SCHEMBL6332023 | 0.76 | JUN (0.50) | KDM4EJUNNFKB1NPC1MAPT | |
| SCHEMBL138489 | 0.76 | MAPT (0.61) | KDM4EJUNNFKB1NPC1MAPT | |
| SCHEMBL107198 | 0.76 | MAPT (0.61) | KDM4EJUNNFKB1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1263731-C | Novel therapeutic immunizing agents and their use in reducing cytokine levels | CELGENE CORP (US) | 2006-07-12 | — | — | CN | claimed |
| CN-115385851-B | Near-infrared aggregation-induced emission type ultra-efficient photosensitizer with asymmetric diacetonitrile-based structure, preparation method and application | 华东理工大学 | 2024-10-18 | — | — | CN | disclosed |
| CN-117003759-A | TB-pyridine cyano vinyl derivative with viscosity response and synthesis and application thereof | 江苏师范大学 | 2023-11-07 | — | — | CN | disclosed |
| CN-115385851-A | Near-infrared aggregation-induced emission type ultra-efficient photosensitizer with asymmetric diacetonitrile structure, and preparation method and application thereof | 华东理工大学 | 2022-11-25 | — | — | CN | disclosed |
| US-20180009783-A1 | SUBSTITUTED 2-[3-(1-METHYL-PIPERIDIN-4-YL)-PROPYLAMINO]-PYRIMIDINE-5-CARBOXYLIC ACIDS AND AMIDES AND METHODS OF MAKING THE SAME | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-11 | — | — | US | disclosed |
| US-9796699-B2 | Substituted 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same | JANSSEN PHARMACEUTICA NV (BE) | 2017-10-24 | — | — | US | disclosed |
| US-9796699-B2 | Substituted 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same | JANSSEN PHARMACEUTICA NV (BE) | 2017-10-24 | — | — | US | disclosed |
| WO-2017076888-A1 | 2-[3-(1-METHYL-PIPERIDIN-4-YL)-PROPYLAMINO]-PYRIMIDINE-5-CARBOXYLIC ACIDS AND AMIDES AND METHODS OF MAKING THE SAME | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-11 | — | — | WO | disclosed |
| US-20170121309-A1 | SUBSTITUTED 2-[3-(1-METHYL-PIPERIDIN-4-YL)-PROPYLAMINO]-PYRIMIDINE-5-CARBOXYLIC ACIDS AND AMIDES AND METHODS OF MAKING THE SAME | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-04 | — | — | US | disclosed |
| US-20170121309-A1 | SUBSTITUTED 2-[3-(1-METHYL-PIPERIDIN-4-YL)-PROPYLAMINO]-PYRIMIDINE-5-CARBOXYLIC ACIDS AND AMIDES AND METHODS OF MAKING THE SAME | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-04 | — | — | US | disclosed |
| US-20050032786-A1 | 1, 3-benzothiazinone derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-02-10 | — | — | US | disclosed |
| US-20040266822-A1 | Amine derivative with potassium channel regulatory function, its preparation and use | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. (CN) | 2004-12-30 | — | — | US | disclosed |
| EP-1424336-A1 | 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2004-06-02 | — | — | EP | disclosed |
| EP-1386908-A1 | AMINE DERIVATIVE WITH POTASSIUM CHANNEL REGULATORY FUNCTION, ITS PREPARATION AND USE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2004-02-04 | — | — | EP | disclosed |
| CN-1379777-A | Amino-triazolopyridine derivatives | HOFFMANN LA ROCHE (CH) | 2002-11-13 | — | — | CN | disclosed |
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | disclosed |
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | disclosed |
| CN-1228080-A | Novel therapeutic immunizing agents and their use in reducing cytokine levels | CELGENE CORP (US) | 1999-09-08 | — | — | CN | disclosed |
| US-4452943-A | ADDING NITRILE-CONTAINING MATERIAL TO NON-POLAR THERMOPLASTIC POLYMER | GOLDMAN CONRAD | 1984-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266822-A1 | Amine derivative with potassium channel regulatory function, its preparation and use | KCNMA1, KCNA5, KCNA1 | KDM4E 551/4885JUN 1427/4885NFKB1 641/4885 |
| US-20180009783-A1 | SUBSTITUTED 2-[3-(1-METHYL-PIPERIDIN-4-YL)-PROPYLAMINO]-PYRIMIDINE-5-CARBOXYLIC ACIDS AND AMIDES AND METHODS OF MAKING THE SAME | DPYD, PAICS, AZI2 | KDM4E 591/4885JUN 1266/4885NFKB1 1966/4885 |
| US-20170121309-A1 | SUBSTITUTED 2-[3-(1-METHYL-PIPERIDIN-4-YL)-PROPYLAMINO]-PYRIMIDINE-5-CARBOXYLIC ACIDS AND AMIDES AND METHODS OF MAKING THE SAME | DPYD, PAICS, AZI2 | KDM4E 591/4885JUN 1266/4885NFKB1 1966/4885 |
| US-20050032786-A1 | 1, 3-benzothiazinone derivatives and use thereof | MIF, MORF4L1, FOXM1 | KDM4E 3627/4885JUN 2748/4885NFKB1 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.