Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26631729 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL29634822 | 0.83 | HPGD (0.52) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL15770914 | 0.78 | HSPB1 (0.51) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL15972175 | 0.77 | POLB (0.51) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL26631738 | 0.77 | MAPT (0.43) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL26631827 | 0.77 | MAPT (0.46) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL15067957 | 0.74 | HSPB1 (0.47) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL29634818 | 0.74 | CTSV (0.41) | SMN1; SMN2PIN1LMNAALDH1A1MEN1 | |
| SCHEMBL27075094 | 0.74 | CTSV (0.41) | SMN1; SMN2PIN1LMNAALDH1A1MEN1 | |
| SCHEMBL31352860 | 0.74 | CTSV (0.50) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240489-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098625-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-05-12 | — | — | WO | disclosed |