Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | SPR | P35270 | 1/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.56 |
| ▸ | KDM5A | P29375 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806341 | 0.87 | HSD11B1 (0.60) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL12791432 | 0.82 | HSD11B1 (0.56) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL4074303 | 0.80 | HSD11B1 (0.53) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL19961308 | 0.80 | ALDH1A1 (0.67) | HSD11B1SPRUSP30KDM5APOLB | |
| SCHEMBL6347014 | 0.79 | HSD11B1 (0.53) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL14413688 | 0.79 | CYP2C9 (0.52) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL14781405 | 0.79 | HSD11B1 (0.52) | HSD11B1SPRUSP30KDM5ADRD4 | |
| SCHEMBL18115645 | 0.79 | GPR119 (0.59) | HSD11B1SPRUSP30KDM5APRMT5 | |
| SCHEMBL19961306 | 0.78 | RAB9A (0.69) | HSD11B1SPRUSP30KDM5APOLB | |
| SCHEMBL15755669 | 0.78 | HSD11B1 (0.51) | HSD11B1SPRUSP30KDM5ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |