Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30502409 | 0.84 | CYP2D6 (0.43) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL29827543 | 0.84 | PAX8 (0.41) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL5608087 | 0.84 | SIGMAR1 (0.40) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL726452 | 0.84 | CA2 (0.47) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL2679932 | 0.84 | CYP2D6 (0.43) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL1660887 | 0.84 | PAX8 (0.41) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL29773602 | 0.84 | CA2 (0.47) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| Hydrochloric Acid SCHEMBL28101819 | 0.83 | EP300 (0.43) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL7595952 | 0.80 | CHEK1 (0.39) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL7298973 | 0.80 | G6PD (0.37) | CHEK1NEK2LIMK1DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338605-B2 | Anti-viral compounds | ABBOTT LABORATORIES (US) | 2012-12-25 | — | — | US | claimed |
| US-20100256139-A1 | Anti-Viral Compounds | ABBOTT LABORATORIES (US) | 2010-10-07 | — | — | US | claimed |
| EP-1979349-B1 | ANTI-VIRAL COMPOUNDS | ABBOTT LAB (US) | 2010-07-28 | — | — | EP | claimed |
| EP-1979349-A2 | ANTI-VIRAL COMPOUNDS | Abbott Laboratories (US) | 2008-10-15 | — | — | EP | claimed |
| US-20070232645-A1 | ANTI-VIRAL COMPOUNDS | ABBVIE INC. | 2007-10-04 | — | — | US | claimed |
| WO-2007076035-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-07-05 | — | — | WO | claimed |
| EP-2719693-B1 | METHOD FOR MANUFACTURING OXETANE COMPOUND, METHOD FOR MANUFACTURING AZOLYLMETHYLCYCLOPENTANOL COMPOUND, AND INTERMEDIATE COMPOUND | KUREHA CORP (JP) | 2016-08-10 | — | — | EP | disclosed |
| US-9278966-B2 | Method for manufacturing oxetane compound, method for manufacturing azolylmethylcyclopentanol compound, and intermediate compound | KUREHA CORPORATION (JP) | 2016-03-08 | — | — | US | disclosed |
| US-9051298-B2 | Method for manufacturing 4-benzyl-1-methyl-6-oxabicyclo[3,2,0]heptane derivative and method for manufacturing azole derivative | KUREHA CORPORATION (JP) | 2015-06-09 | — | — | US | disclosed |
| US-8962871-B2 | Method for producing 4-benzyl-1-methyl-6-oxabicyclo[3,2,0]heptane derivative | KUREHA CORPORATION (JP) | 2015-02-24 | — | — | US | disclosed |
| EP-2813501-A1 | METHOD FOR PRODUCING 4-BENZYL-1-METHYL-6-OXABICYCLO[3,2,0]HEPTANE DERIVATIVE | Kureha Corporation (JP) | 2014-12-17 | — | — | EP | disclosed |
| US-20140336389-A1 | METHOD FOR MANUFACTURING 4-BENZYL-1-METHYL-6-OXABICYCLO[3,2,0]HEPTANE DERIVATIVE AND METHOD FOR MANUFACTURING AZOLE DERIVATIVE | KUREHA CORPORATION (JP) | 2014-11-13 | — | — | US | disclosed |
| US-20140296535-A1 | METHOD FOR PRODUCING 4-BENZYL-1-METHYL-6-OXABICYCLO[3,2,0]HEPTANE DERIVATIVE | KUREHA CORPORATION (JP) | 2014-10-02 | — | — | US | disclosed |
| US-8338605-B2 | Anti-viral compounds | ABBOTT LABORATORIES (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100256139-A1 | Anti-Viral Compounds | ABBOTT LABORATORIES (US) | 2010-10-07 | — | — | US | disclosed |
| EP-1979349-B1 | ANTI-VIRAL COMPOUNDS | ABBOTT LAB (US) | 2010-07-28 | — | — | EP | disclosed |
| US-7763731-B2 | Anti-viral compounds | ABBOTT LABORATORIES (US) | 2010-07-27 | — | — | US | disclosed |
| EP-1979349-A2 | ANTI-VIRAL COMPOUNDS | Abbott Laboratories (US) | 2008-10-15 | — | — | EP | disclosed |
| US-20070232645-A1 | ANTI-VIRAL COMPOUNDS | ABBVIE INC. | 2007-10-04 | — | — | US | disclosed |
| WO-2007076035-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296535-A1 | METHOD FOR PRODUCING 4-BENZYL-1-METHYL-6-OXABICYCLO[3,2,0]HEPTANE DERIVATIVE | CYP2B6, CYP2F1, CYP1B1 | CHEK1 4565/4885NEK2 2906/4885LIMK1 4591/4885 |
| US-20070232645-A1 | ANTI-VIRAL COMPOUNDS | HAVCR2, MAVS, EIF2AK2 | CHEK1 3957/4885NEK2 3397/4885LIMK1 3171/4885 |
| US-20140336389-A1 | METHOD FOR MANUFACTURING 4-BENZYL-1-METHYL-6-OXABICYCLO[3,2,0]HEPTANE DERIVATIVE AND METHOD FOR MANUFACTURING AZOLE DERIVATIVE | CYP1B1, CYP4B1, CYP4F11 | CHEK1 4395/4885NEK2 3334/4885LIMK1 4619/4885 |
| US-20100256139-A1 | Anti-Viral Compounds | HAVCR2, MAVS, EIF2AK2 | CHEK1 3957/4885NEK2 3397/4885LIMK1 3171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.