SCHEMBL29649526

SCHEMBL29649526

Cc1ccc(C(NCCCC[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)Nc2ccc(CO)cc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MDM2 Q00987 3/20 0.45
▸ SIRT2 Q8IXJ6 6/20 0.42
▸ SIRT1 Q96EB6 5/20 0.42
▸ SIRT3 Q9NTG7 3/20 0.41
▸ TLR2 O60603 2/20 0.40
▸ SIRT5 Q9NXA8 1/20 0.40
▸ MDM4 O15151 1/20 0.40
▸ TP53 P04637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31681574 1.00 MDM2 (0.45) MDM2SIRT2SIRT1SIRT3TLR2
SCHEMBL30518584 0.95 PTPN1 (0.45) MDM2SIRT2SIRT1
SCHEMBL26066849 0.93 MDM2 (0.47) MDM2SIRT2SIRT1SIRT3TLR2
SCHEMBL30447741 0.93 MDM2 (0.47) MDM2SIRT2SIRT1SIRT3TLR2
SCHEMBL29649433 0.90 MDM2 (0.44) MDM2SIRT2SIRT1SIRT3TLR2
SCHEMBL25361944 0.89 MDM2 (0.43) MDM2SIRT2SIRT1SIRT3TLR2
SCHEMBL25361941 0.89 MDM2 (0.43) MDM2SIRT2SIRT1SIRT3TLR2
SCHEMBL29649545 0.89 MAPT (0.51) SIRT5
SCHEMBL29589438 0.88 MDM2 (0.42) MDM2SIRT2SIRT1SIRT3SIRT5
SCHEMBL25361276 0.88 PTPN1 (0.46) MDM2SIRT2SIRT1SIRT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4237008-A2 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF Elucida Oncology, Inc. (US) 2023-09-06 — — EP disclosed
US-20230241243-A1 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF ELUCIDA ONCOLOGY, INC. 2023-08-03 — — US disclosed
WO-2022093800-A2 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF ELUCIDA ONCOLOGY, INC. (US) 2022-05-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230241243-A1 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF NDC1, KIFC1, SDCBP MDM2 942/4885SIRT2 2798/4885SIRT1 2353/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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