SCHEMBL29649433

SCHEMBL29649433

COC(=O)c1ccc(NC(=O)[C@H](CCCCNC(c2ccccc2)(c2ccccc2)c2ccc(C)cc2)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MDM2 Q00987 4/20 0.44
▸ TLR2 O60603 3/20 0.43
▸ SIRT2 Q8IXJ6 5/20 0.40
▸ SIRT1 Q96EB6 5/20 0.40
▸ MDM4 O15151 1/20 0.39
▸ TP53 P04637 1/20 0.39
▸ KLKB1 P03952 1/20 0.39
▸ SIRT3 Q9NTG7 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29649551 0.94 CASP3 (0.42) MDM2TLR2SIRT2SIRT1KLKB1
SCHEMBL29649526 0.90 MDM2 (0.45) MDM2TLR2SIRT2SIRT1MDM4
SCHEMBL31681574 0.90 MDM2 (0.45) MDM2TLR2SIRT2SIRT1MDM4
SCHEMBL25361941 0.90 MDM2 (0.43) MDM2TLR2SIRT2SIRT1MDM4
SCHEMBL25361944 0.90 MDM2 (0.43) MDM2TLR2SIRT2SIRT1MDM4
SCHEMBL29649631 0.86 MDM2 (0.43) MDM2TLR2SIRT2SIRT1MDM4
SCHEMBL30518584 0.86 PTPN1 (0.45) MDM2SIRT2SIRT1
SCHEMBL6158363 0.86 MDM2 (0.57) MDM2TLR2MDM4TP53
SCHEMBL436024 0.86 MDM2 (0.57) MDM2TLR2MDM4TP53
SCHEMBL31681399 0.86 MDM2 (0.57) MDM2TLR2MDM4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4237008-A2 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF Elucida Oncology, Inc. (US) 2023-09-06 — — EP disclosed
US-20230241243-A1 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF ELUCIDA ONCOLOGY, INC. 2023-08-03 — — US disclosed
WO-2022093800-A2 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF ELUCIDA ONCOLOGY, INC. (US) 2022-05-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230241243-A1 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF NDC1, KIFC1, SDCBP MDM2 942/4885TLR2 3403/4885SIRT2 2798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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