Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 5/20 | 0.36 |
| ▸ | TDO2 | P48775 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18183345 | 0.89 | CNR1 (0.48) | CNR1EIF4A3MEN1KMT2AGHSR | |
| SCHEMBL16234661 | 0.78 | EIF4A3 (0.51) | CNR1EIF4A3IDO1TDO2KDM4E | |
| SCHEMBL1144892 | 0.77 | EIF4A3 (0.63) | CNR1EIF4A3MEN1KMT2AIDO1 | |
| SCHEMBL29655546 | 0.77 | EIF4A3 (0.63) | CNR1EIF4A3MEN1KMT2AIDO1 | |
| SCHEMBL29897794 | 0.77 | ULK1 (0.49) | CNR1EIF4A3MEN1KMT2AIDO1 | |
| SCHEMBL4276853 | 0.77 | ULK1 (0.49) | CNR1EIF4A3MEN1KMT2AIDO1 | |
| SCHEMBL30536697 | 0.77 | IDO1 (0.38) | EIF4A3IDO1TDO2ALOX15 | |
| SCHEMBL30147453 | 0.76 | NPC1 (0.48) | CNR1EIF4A3MEN1KMT2AKDM4E | |
| SCHEMBL24448445 | 0.74 | EIF4A3 (0.47) | CNR1EIF4A3GHSRIDO1TDO2 | |
| SCHEMBL30147573 | 0.74 | EIF4A3 (0.47) | CNR1EIF4A3GHSRIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540141-B2 | Spiropyrrolidine derived antiviral agents | ENANTA PHARMACEUTICALS, INC. (US) | 2026-02-03 | — | — | US | disclosed |
| CN-116621917-A | Difluoro indole-spiro compound and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2023-08-22 | — | — | CN | disclosed |
| US-20230103494-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2023-04-06 | — | — | US | disclosed |
| CN-114524821-A | Novel spiropyrrolidine derived antiviral drugs | 英安塔制药有限公司 | 2022-05-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103494-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ACE, ACE2, REN | CNR1 1707/4885EIF4A3 179/4885MEN1 4168/4885 |
| US-12540141-B2 | Spiropyrrolidine derived antiviral agents | ACE2, NR3C2, ACE | CNR1 248/4885EIF4A3 352/4885MEN1 3954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.