Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Salethamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | POLR1A | O95602 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salethamide SCHEMBL126228 | 1.00 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDNAAAAPP | |
| Salethamide SCHEMBL588724 | 0.92 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDNAAAAPP | |
| Salethamide SCHEMBL11573255 | 0.90 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDNAAAAPP | |
| SCHEMBL8640837 | 0.83 | NAAA (0.67) | ALDH1A1KDM4EHPGDNAAAAPP | |
| SCHEMBL14035537 | 0.83 | HTT (0.59) | ALDH1A1KDM4EHPGDNAAATSHR | |
| SCHEMBL24503506 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL12447795 | 0.77 | HPGD (0.71) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL14868417 | 0.77 | NAAA (0.58) | ALDH1A1KDM4EHPGDNAAATSHR | |
| SCHEMBL8639778 | 0.77 | NAAA (0.60) | ALDH1A1KDM4EHPGDNAAATSHR | |
| SCHEMBL14872241 | 0.77 | NAAA (0.54) | ALDH1A1KDM4EHPGDNAAAAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118613231-A | Orthodontic device for delivering active agents | 斯米利奥公司 | 2024-09-06 | — | — | CN | disclosed |
| CN-116940351-A | Prodrug compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-115038451-A | Multimodal compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-115003279-A | Prodrug compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| EP-3999592-A1 | THERANOSTIC CONJUGATES | Ariel Scientific Innovations Ltd. (IL) | 2022-05-25 | — | — | EP | disclosed |