Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 11/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 11/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21823272 | 1.00 | HTR1A (0.41) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL23976562 | 0.85 | ALDH1A1 (0.44) | CYP3A4ALDH1A1AXLPOLBL3MBTL1 | |
| SCHEMBL18220679 | 0.83 | P2RX3 (0.37) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL31215476 | 0.81 | P2RX3 (0.31) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL17310145 | 0.78 | AXL (0.43) | HTR2AHTR2CHTR2BP2RX3P2RX2 | |
| SCHEMBL31390132 | 0.78 | AXL (0.43) | HTR2AHTR2CHTR2BP2RX3P2RX2 | |
| SCHEMBL22759822 | 0.77 | NQO2 (0.41) | P2RX3P2RX2LMNAALDH1A1AXL | |
| SCHEMBL18985638 | 0.77 | P2RX3 (0.40) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL22925704 | 0.75 | ALOX5 (0.39) | CYP1A2CYP3A4TSHRNFKB1LMNA | |
| SCHEMBL19616297 | 0.75 | L3MBTL1 (0.52) | CYP3A4TSHRP2RX3P2RX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4532493-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF | Ideaya Biosciences, Inc. (US) | 2025-04-09 | — | — | EP | disclosed |
| CN-118908960-A | Nitrogen-containing heteroaryl compound, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-11-08 | — | — | CN | disclosed |
| WO-2023233295-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF | IDEAYA BIOSCIENCES, INC. (US) | 2023-12-07 | — | — | WO | disclosed |
| EP-4255573-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |