Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15761208 | 1.00 | TAS2R14 (0.46) | TAS2R14CTSSMLYCDDHODHHDAC6 | |
| SCHEMBL1125455 | 0.86 | HDAC8 (0.49) | TAS2R14CTSSMLYCDMAOBGPBAR1 | |
| SCHEMBL8575500 | 0.86 | LMNA (0.49) | MLYCDMAOBGPBAR1SMN1; SMN2LMNA | |
| SCHEMBL21401288 | 0.80 | ESR1 (0.55) | MLYCDSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL30577974 | 0.79 | MLYCD (0.42) | CTSSMLYCDMAOBGPBAR1SMN1; SMN2 | |
| SCHEMBL726068 | 0.78 | TAS2R14 (0.54) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL16625279 | 0.77 | CTSS (0.51) | TAS2R14CTSSMLYCDDHODHHDAC6 | |
| SCHEMBL28052031 | 0.77 | TAS2R14 (0.55) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL4837622 | 0.76 | KMT2A (0.41) | MLYCDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL14381951 | 0.76 | ESR1 (0.36) | MLYCDMAOBSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655625-A | Compounds as SOS1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-115785088-A | Compounds as SOS1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-114685488-A | Compounds as SOS1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2022-07-01 | — | — | CN | disclosed |