Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 12/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722 | 1.00 | BDKRB1 (0.36) | BDKRB1BRS3PDCD1CD274SCN1A | |
| SCHEMBL3020 | 0.85 | SCN1A (0.42) | BDKRB1PDCD1CD274SCN1ASCN2A | |
| SCHEMBL2721 | 0.85 | BDKRB1 (0.39) | BDKRB1BRS3PDCD1CD274SCN1A | |
| SCHEMBL2970 | 0.85 | BDKRB1 (0.39) | BDKRB1BRS3PDCD1CD274SCN1A | |
| SCHEMBL3036 | 0.83 | SLC6A4 (0.46) | BDKRB1BRS3PDCD1CD274SCN1A | |
| SCHEMBL3055 | 0.77 | LTB4R2 (0.47) | LTB4R2AGTR1 | |
| SCHEMBL2127 | 0.73 | SCN1A (0.50) | BDKRB1BRS3SCN1ASCN2ASCN3A | |
| SCHEMBL3202 | 0.71 | SCN1A (0.51) | BDKRB1BRS3SCN1ASCN2ASCN3A | |
| SCHEMBL2302 | 0.70 | SCN1A (0.51) | SCN1ASCN2ASCN3A | |
| SCHEMBL3019 | 0.69 | ADRB3 (0.42) | BDKRB1PDCD1CD274SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |