Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927314 | 1.00 | ALDH1A1 (0.50) | ALDH1A1HSD17B10KDM4EL3MBTL1HSD11B1 | |
| Hydrochloric Acid SCHEMBL31731478 | 0.98 | ALDH1A1 (0.48) | ALDH1A1HSD17B10KDM4EL3MBTL1HSD11B1 | |
| SCHEMBL1852870 | 0.84 | FFAR1 (0.48) | ALDH1A1HSD17B10MAP3K11MEN1KMT2A | |
| SCHEMBL23069 | 0.83 | NPC1 (0.56) | ALDH1A1HSD17B10KDM4EL3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL27543158 | 0.81 | NPC1 (0.55) | ALDH1A1HSD17B10KDM4EL3MBTL1NPC1 | |
| SCHEMBL29265410 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HSD17B10L3MBTL1HSD11B1NPC1 | |
| SCHEMBL13394608 | 0.80 | APP (0.40) | ALDH1A1HSD17B10KDM4EL3MBTL1HSD11B1 | |
| SCHEMBL30954741 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HSD17B10L3MBTL1HSD11B1NPC1 | |
| Ethane SCHEMBL27382338 | 0.79 | NPC1 (0.53) | ALDH1A1HSD17B10KDM4EL3MBTL1NPC1 | |
| SCHEMBL3310695 | 0.79 | L3MBTL1 (0.42) | ALDH1A1HSD17B10KDM4EL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250109139-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES (CN) | 2025-04-03 | — | — | US | disclosed |
| US-20240124456-A1 | AZA-ERGOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SHANGHAITECH UNIVERSITY (CN) | 2024-04-18 | — | — | US | disclosed |
| EP-4286384-A1 | AZA-ERGOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | ShanghaiTech University (CN) | 2023-12-06 | — | — | EP | disclosed |
| WO-2022161493-A1 | AZA-ERGOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海科技大学 | 2022-08-04 | — | — | WO | disclosed |
| CN-114835709-A | Aza-ergoline derivative and preparation method and application thereof | 上海科技大学 | 2022-08-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124456-A1 | AZA-ERGOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | ERG, CHRNA7, CHRNA5 | ALDH1A1 399/4885HSD17B10 1448/4885KDM4E 2460/4885 |
| US-20250109139-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | PARK7, HADH, BDNF | ALDH1A1 1460/4885HSD17B10 677/4885KDM4E 4265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.