Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 3/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ADIPOR2 | Q86V24 | 1/20 | 0.40 |
| ▸ | ADIPOR1 | Q96A54 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2972824 | 0.88 | ATF4 (0.59) | ATF4ADAMTS5ADAMTS4POLBALDH1A1 | |
| SCHEMBL2987483 | 0.87 | ATF4 (0.61) | ATF4POLBALDH1A1USP2ADIPOR2 | |
| SCHEMBL2989386 | 0.84 | LMNA (0.45) | ATF4POLBLMNAEPHX1 | |
| SCHEMBL2985381 | 0.84 | OPRM1 (0.48) | EPHX2EPHX1 | |
| SCHEMBL2978761 | 0.82 | ATF4 (0.65) | ATF4POLBALDH1A1LMNA | |
| SCHEMBL2986952 | 0.81 | MEN1 (0.47) | ATF4LMNA | |
| SCHEMBL2981366 | 0.79 | EPHX2 (0.50) | EPHX2EPHX1 | |
| SCHEMBL2976726 | 0.79 | MCHR1 (0.54) | POLBSMN1; SMN2 | |
| SCHEMBL2977995 | 0.79 | THRB (0.48) | SMN1; SMN2EPHX2 | |
| SCHEMBL2987178 | 0.79 | ATF4 (0.58) | ATF4POLBLMNASMN1; SMN2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747191-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005110975-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | disclosed |