Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 14/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2979399 | 0.85 | ADORA2A (0.48) | ALDH1A1MEN1KMT2ACYP1A2ADORA1 | |
| SCHEMBL2974174 | 0.81 | SQOR (0.39) | ALDH1A1MEN1KMT2ACYP1A2NPC1 | |
| SCHEMBL5671301 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL7219981 | 0.76 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL554431 | 0.76 | PTGS1 (0.38) | ALDH1A1KMT2AL3MBTL1NPC1MAPT | |
| SCHEMBL5329331 | 0.75 | ADORA1 (0.56) | ADORA1ADORA2AHSD17B10 | |
| SCHEMBL15748249 | 0.73 | MEN1 (0.35) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL30679309 | 0.73 | PRKACA (0.36) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL398500 | 0.72 | PTGS1 (0.39) | ALDH1A1MAPTHSD17B10 | |
| SCHEMBL24311363 | 0.71 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | claimed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | claimed |