SCHEMBL2979865

SCHEMBL2979865

CNC(=O)CN(CC1CCN(CCc2cccc(Cl)c2)CC1)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.45
SLC6A4 P31645 1/20 0.45
OPRM1 P35372 1/20 0.45
SIGMAR1 Q99720 2/20 0.44
CARM1 Q86X55 1/20 0.44
PRMT6 Q96LA8 1/20 0.44
KCNH2 Q12809 1/20 0.43
CACNA1I Q9P0X4 1/20 0.43
UBE2M P61081 1/20 0.42
DCUN1D1 Q96GG9 1/20 0.42
CCR5 P51681 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
GLA P06280 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2970396 0.84 DRD4 (0.47) HTR1ASLC6A4SIGMAR1
SCHEMBL2975028 0.84 ARG1 (0.44) HTR1ASLC6A4SIGMAR1CCR5L3MBTL1
SCHEMBL2982100 0.81 CCR3 (0.42) OPRM1SIGMAR1KCNH2L3MBTL1KDM4E
SCHEMBL2970167 0.80 SIGMAR1 (0.49) SIGMAR1
Hydrochloric Acid SCHEMBL2971261 0.79 SIGMAR1 (0.48) SIGMAR1
SCHEMBL2982820 0.78 HTR1A (0.46) HTR1ASLC6A4OPRM1SIGMAR1
SCHEMBL2981930 0.78 DRD3 (0.46) OPRM1SIGMAR1KCNH2
SCHEMBL2980735 0.77
SCHEMBL2983973 0.77 SIGMAR1 (0.51) HTR1ASIGMAR1L3MBTL1ALDH1A1
SCHEMBL2965450 0.77 NPC1 (0.39) L3MBTL1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7781590-B2 Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors SANOFI-AVENTIS (FR) 2010-08-24 US disclosed
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS FAAH, FAAH2, CNR2 HTR1A 893/4885SLC6A4 1489/4885OPRM1 627/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.