Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | TK1 | P04183 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31257840 | 0.80 | TNKS2 (0.45) | ALDH1A1TNKS2PARP2ERCC1ERCC5 | |
| SCHEMBL6723373 | 0.78 | ALDH1A1 (0.59) | ALDH1A1CYP2C9CYP2C19TK1SMN1; SMN2 | |
| SCHEMBL6719602 | 0.72 | ALDH1A1 (0.75) | ALDH1A1CYP2C9CYP2C19TK1SMN1; SMN2 | |
| SCHEMBL6670689 | 0.71 | ALDH1A1 (0.40) | ALDH1A1TNKS2PARP2ERCC1ERCC5 | |
| SCHEMBL19994153 | 0.71 | ERCC1 (0.36) | ALDH1A1TNKS2PARP2ERCC1ERCC5 | |
| SCHEMBL7507593 | 0.70 | DAO (0.53) | ALDH1A1TNKS2ERCC1ERCC5FEN1 | |
| SCHEMBL27691590 | 0.69 | ALDH1A1 (0.70) | ALDH1A1CYP2C9CYP2C19TK1SMN1; SMN2 | |
| SCHEMBL27691593 | 0.69 | ALDH1A1 (0.55) | ALDH1A1CYP2C9CYP2C19TK1SMN1; SMN2 | |
| SCHEMBL9597854 | 0.68 | ALDH1A1 (0.53) | ALDH1A1CYP2C9CYP2C19TK1SMN1; SMN2 | |
| SCHEMBL27691591 | 0.68 | ALDH1A1 (0.56) | ALDH1A1CYP2C9CYP2C19TK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776868-B2 | Substituted bicyclic and tricyclic thieno[2,3-d]pyrimidines as A2A adenosine receptor antagonists | GILEAD PALO ALTO, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20080188495-A1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188495-A1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | ADORA2A, ADORA3, ADORA1 | ALDH1A1 925/4885TNKS2 1554/4885PARP2 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.