SCHEMBL2981243

SCHEMBL2981243

C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12C1CC(=O)C=C2CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@@H]3[C@]21C

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 10/20 0.60
NR3C1 P04150 7/20 0.60
SERPINA6 P08185 4/20 0.60
ALDH1A1 P00352 3/20 0.60
LMNA P02545 3/20 0.60
SHBG P04278 3/20 0.60
CYP3A4 P08684 3/20 0.60
SMN1; SMN2 Q16637 3/20 0.60
TSHR P16473 3/20 0.60
PMP22 Q01453 2/20 0.60
CYP2D6 P10635 1/20 0.60
KCNA1 Q09470 1/20 0.60
SLC47A1 Q96FL8 1/20 0.60
MAPK1 P28482 1/20 0.53
CYP2C19 P33261 4/20 0.52
HIF1A Q16665 5/20 0.51
KMT2A Q03164 3/20 0.51
PGR P06401 3/20 0.51
MEN1 O00255 2/20 0.51
SLC29A1 Q99808 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL94105 0.88 HIF1A (0.63) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
SCHEMBL28318620 0.85 HIF1A (0.60) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
SCHEMBL2330386 0.85 NR3C1 (0.59) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
SCHEMBL8061818 0.85 HIF1A (0.59) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
SCHEMBL6370137 0.85 HIF1A (0.59) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
SCHEMBL8907648 0.84 NR3C1 (0.56) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
Butyric Acid SCHEMBL28142317 0.83 HIF1A (0.57) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
SCHEMBL28957729 0.83 HSD17B10 (0.55) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
SCHEMBL342689 0.82 HSD17B10 (0.71) HSD17B10NR3C1SERPINA6ALDH1A1LMNA
SCHEMBL8217259 0.82 HSD17B10 (0.71) HSD17B10NR3C1SERPINA6ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230141499-A1 CARDIOSPHERE-DERIVED CELL (CDC) THERAPY FOR THE TREATMENT OF VIRAL INFECTIONS CEDARS-SINAI MEDICAL CENTER 2023-05-11 US claimed
WO-2021188899-A1 CARDIOSPHERE-DERIVED CELL (CDC) THERAPY FOR THE TREATMENT OF VIRAL INFECTIONS CEDARS-SINAI MEDICAL CENTER (US) 2021-09-23 WO claimed
WO-2023240222-A2 IMMUNE TOLERANCE INDUCTION TO VIRAL CAPSIDS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2023-12-14 WO disclosed
WO-2023178337-A2 METHODS AND COMPOSITIONS FOR TREATING RBM20 RELATED CARDIOMYOPATHY WITH A VIRAL VECTOR UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2023-09-21 WO disclosed
WO-2023178338-A2 METHODS AND COMPOSITIONS FOR TREATING TMEM43 RELATED CARDIOMYOPATHY WITH A VIRAL VECTOR UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2023-09-21 WO disclosed
WO-2023178339-A2 METHODS AND COMPOSITIONS FOR TREATING TNNT2 RELATED CARDIOMYOPATHY WITH A VIRAL VECTOR UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2023-09-21 WO disclosed
WO-2023108157-A1 METHODS AND COMPOSITIONS FOR TREATING MYBPC3 RELATED HYPERTROPHIC CARDIOMYOPATHY WITH A VIRAL VECTOR UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2023-06-15 WO disclosed
WO-2023108159-A1 METHODS AND COMPOSITIONS FOR TREATING BAG-3 RELATED CARDIOMYOPATHY WITH A VIRAL VECTOR UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2023-06-15 WO disclosed
WO-2023108130-A2 COMPOSITIONS COMPRISING KOZAK SEQUENCES SELECTED FOR ENHANCED EXPRESSION AAVANTIBIO, INC. (US) 2023-06-15 WO disclosed
US-20230141499-A1 CARDIOSPHERE-DERIVED CELL (CDC) THERAPY FOR THE TREATMENT OF VIRAL INFECTIONS CEDARS-SINAI MEDICAL CENTER 2023-05-11 US disclosed
WO-2021202599-A2 ADENO-ASSOCIATED VIRUS BASED COMPOSITIONS AND RELATED METHODS FOR INDUCING HUMORAL IMMUNITY VALIANT BIOSCIENCES, LLC (US) 2021-10-07 WO disclosed
US-20140024636-A1 SULFAMIDE DERIVATIVE HAVING AN ADAMANTYL GROUP AND ITS PHARMACEUTICALLY ACCEPTABLE SALT KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2014-01-23 US disclosed
US-7780982-B2 Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition INDUSTRIAL TECHNOLOGY RESEARCH INSTITTUTE (TW) 2010-08-24 US disclosed
EP-1538166-B1 Hyaluronic acid derivative with urethane linkage IND TECH RES INST (TW) 2009-02-18 EP disclosed
CN-101001842-A Amido compounds and their use as pharmaceuticals INCYTE CORP (US) 2007-07-18 CN disclosed
US-20050123505-A1 Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2005-06-09 US disclosed
EP-1538166-A1 Biodegradable hyaluronic acid derivative and composition containing micelles made therefom INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2005-06-08 EP disclosed
US-5326761-A Suspension; sustained release MERCK SHARP & DOHME-CHIBRET (FR) 1994-07-05 US disclosed
EP-0437368-B1 Fluid ophthalmic composition based on lipid microparticles containing at least one active principle MERCK SHARP & DOHME (FR) 1994-03-02 EP disclosed
EP-0437368-A1 Fluid ophthalmic composition based on lipid microparticles containing at least one active principle LABORATOIRES MERCK, SHARP & DOHME-CHIBRET (FR) 1991-07-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024636-A1 SULFAMIDE DERIVATIVE HAVING AN ADAMANTYL GROUP AND ITS PHARMACEUTICALLY ACCEPTABLE SALT HSD11B1, HSD11B2, HSD3B1 HSD17B10 21/4885NR3C1 177/4885SERPINA6 877/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.