SCHEMBL29831769

SCHEMBL29831769

Cc1ccc(C(CC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)c2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
LMNA P02545 4/20 0.42
SMN1; SMN2 Q16637 4/20 0.42
PTPN1 P18031 5/20 0.41
HSD17B10 Q99714 1/20 0.40
RAB9A P51151 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
NPC1 O15118 1/20 0.39
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
MITF O75030 1/20 0.37
HTT P42858 1/20 0.37
GFER P55789 1/20 0.37
PAX8 Q06710 1/20 0.37
ATM Q13315 1/20 0.37
MGAM O43451 1/20 0.37
GAA P10253 1/20 0.37
SI P14410 1/20 0.37
MGAM2 Q2M2H8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29832039 0.95 LMNA (0.46) ALDH1A1LMNASMN1; SMN2PTPN1HSD17B10
SCHEMBL29832138 0.93 CA2 (0.41) ALDH1A1LMNASMN1; SMN2HSD17B10CES2
SCHEMBL29832008 0.90 PTPN1 (0.48) ALDH1A1LMNASMN1; SMN2PTPN1HSD17B10
SCHEMBL29831753 0.87 NTSR1 (0.43) ALDH1A1LMNASMN1; SMN2PTPN1HSD17B10
SCHEMBL29832000 0.87 HSP90AA1 (0.42) ALDH1A1LMNASMN1; SMN2PTPN1HSD17B10
SCHEMBL29832085 0.86 CES2 (0.38) ALDH1A1LMNASMN1; SMN2PTPN1HSD17B10
SCHEMBL29831903 0.86 ALDH1A1 (0.48) ALDH1A1LMNASMN1; SMN2RAB9AMEN1
SCHEMBL29832463 0.82 NTSR1 (0.49) ALDH1A1LMNASMN1; SMN2PTPN1HSD17B10
SCHEMBL29832144 0.82 NTSR1 (0.47) ALDH1A1LMNASMN1; SMN2PTPN1HSD17B10
SCHEMBL29832215 0.81 ALDH1A1 (0.54) ALDH1A1LMNASMN1; SMN2HSD17B10RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115093367-A Preparation method and application of fluoroalkyl ketone compound 华南农业大学 2022-09-23 CN disclosed