Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077427 | 0.76 | HSD17B10 (0.39) | HSD17B10SMN1; SMN2CA12CA1CA9 | |
| SCHEMBL6396268 | 0.72 | POLB (0.43) | HSD17B10SMN1; SMN2GLAKMT2AHTT | |
| SCHEMBL27921097 | 0.70 | KDM4E (0.38) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL7207146 | 0.70 | L3MBTL1 (0.33) | HSD17B10SMN1; SMN2CA12CA1CA9 | |
| SCHEMBL1535150 | 0.70 | CA12 (0.37) | CA12CA1CA9KDM4EMAPT | |
| SCHEMBL4057481 | 0.69 | KDM4E (0.37) | HSD17B10SMN1; SMN2CA12CA1CA9 | |
| SCHEMBL7015140 | 0.69 | SMN1; SMN2 (0.39) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL8939927 | 0.69 | HTT (0.38) | HSD17B10SMN1; SMN2CA12CA1CA9 | |
| SCHEMBL1535149 | 0.68 | CA12 (0.39) | HSD17B10CA12CA1CA9KDM4E | |
| SCHEMBL8779695 | 0.68 | ALDH1A1 (0.50) | HSD17B10SMN1; SMN2TP53KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250064743-A1 | TREPROSTINIL DERIVATIVES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UNITED THERAPEUTICS CORPORATION (US) | 2025-02-27 | — | — | US | claimed |
| US-12168071-B2 | Treprostinil derivatives and their use in pharmaceutical compositions | UNITED THERAPEUTICS CORPORATION (US) | 2024-12-17 | — | — | US | claimed |
| US-20220280430-A1 | TREPROSTINIL DERIVATIVES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UNITED THERAPEUTICS CORPORATION (US) | 2022-09-08 | — | — | US | claimed |
| US-20250064743-A1 | TREPROSTINIL DERIVATIVES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UNITED THERAPEUTICS CORPORATION (US) | 2025-02-27 | — | — | US | disclosed |
| US-12168071-B2 | Treprostinil derivatives and their use in pharmaceutical compositions | UNITED THERAPEUTICS CORPORATION (US) | 2024-12-17 | — | — | US | disclosed |
| CN-117479946-A | Dry powder compositions containing treprostinil and its prodrug and further comprising (E) -3,6-bis [4- (N-carbonyl-2-propenyl) amide butyl ] -2,5-diketopiperazine (FDKP) | 联合治疗公司 | 2024-01-30 | — | — | CN | disclosed |
| US-20220280430-A1 | TREPROSTINIL DERIVATIVES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UNITED THERAPEUTICS CORPORATION (US) | 2022-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220280430-A1 | TREPROSTINIL DERIVATIVES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | TREH, TKT, TPP2 | HSD17B10 1692/4885SMN1; SMN2 2845/4885CA12 3577/4885 |
| US-20250064743-A1 | TREPROSTINIL DERIVATIVES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | TREH, THPO, TPP2 | HSD17B10 2425/4885SMN1; SMN2 4023/4885CA12 3930/4885 |
| US-12168071-B2 | Treprostinil derivatives and their use in pharmaceutical compositions | TREH, TKT, TPP2 | HSD17B10 1692/4885SMN1; SMN2 2845/4885CA12 3577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.