Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330766 | 0.71 | L3MBTL1 (0.58) | MAPTPIK3CANNMTKDM4E | |
| SCHEMBL17680565 | 0.70 | MAOA (0.59) | MAPTMAOAMAOBKDM4E | |
| SCHEMBL25960452 | 0.69 | MAPT (0.40) | MAPTACSS2NNMTKDM4E | |
| SCHEMBL15242237 | 0.68 | PIK3CB (0.59) | MAPTACSS2KDM4E | |
| SCHEMBL29856207 | 0.68 | MAPT (0.44) | MAPTDHFRPDE10AKDM4E | |
| SCHEMBL16452837 | 0.67 | MAPT (0.50) | MAPTDHFR | |
| SCHEMBL3750423 | 0.66 | GPR35 (0.58) | ACSS2ROCK1KDM4E | |
| SCHEMBL25460382 | 0.66 | LOXL2 (0.48) | MAPT | |
| SCHEMBL29856253 | 0.65 | ERN1 (0.35) | MAPTACSS2CRHR1NNMT | |
| SCHEMBL24110443 | 0.65 | MAPT (0.45) | MAPTACSS2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |