Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28891616 | 1.00 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CSCN10ATNIK | |
| SCHEMBL29875994 | 0.88 | KDM4E (0.41) | TNIKCHEK1ROS1FLT3KDM4E | |
| SCHEMBL28891734 | 0.88 | KDM4E (0.41) | TNIKCHEK1ROS1FLT3KDM4E | |
| SCHEMBL28891628 | 0.87 | SLC2A1 (0.41) | TNIKCDK2PLK4CHEK1PRKD3 | |
| SCHEMBL28891635 | 0.87 | SLC2A1 (0.41) | TNIKCDK2PLK4CHEK1PRKD3 | |
| SCHEMBL28891852 | 0.85 | EML4 (0.47) | ROS1FLT3PIM1EML4ALK | |
| SCHEMBL29876463 | 0.85 | EML4 (0.47) | ROS1FLT3PIM1EML4ALK | |
| SCHEMBL28891739 | 0.84 | SLC2A1 (0.39) | ADRA2AADRA2CCDK2KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL28891676 | 0.80 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CTNIKCDK2 | |
| Trifluoroacetic Acid SCHEMBL29876164 | 0.80 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CTNIKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197154-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |