Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28891629 | 0.87 | SLC2A1 (0.47) | SLC2A1AURKAEML4ALKADRA2A | |
| SCHEMBL28891734 | 0.87 | KDM4E (0.41) | SLC2A1KDM4ETP53MAPK14EML4 | |
| SCHEMBL29875994 | 0.87 | KDM4E (0.41) | SLC2A1KDM4ETP53MAPK14EML4 | |
| SCHEMBL29875779 | 0.84 | ADRA2A (0.41) | SLC2A1KDM4ETP53AURKAHRH4 | |
| SCHEMBL28891616 | 0.84 | ADRA2A (0.41) | SLC2A1KDM4ETP53AURKAHRH4 | |
| SCHEMBL28891628 | 0.82 | SLC2A1 (0.41) | SLC2A1TP53AURKAEML4ALK | |
| SCHEMBL28891635 | 0.80 | SLC2A1 (0.41) | SLC2A1TP53AURKAEML4ALK | |
| SCHEMBL29875822 | 0.79 | KDM4E (0.38) | KDM4ETP53MAPK14EML4ALK | |
| SCHEMBL28891852 | 0.74 | EML4 (0.47) | HRH4EML4ALK | |
| SCHEMBL29876463 | 0.74 | EML4 (0.47) | HRH4EML4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197154-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |