Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.40 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29875994 | 1.00 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10TNIKEML4 | |
| SCHEMBL29875822 | 0.92 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10TNIKEML4 | |
| SCHEMBL28891616 | 0.88 | ADRA2A (0.41) | KDM4EALDH1A1TNIKEML4ALK | |
| SCHEMBL29875779 | 0.88 | ADRA2A (0.41) | KDM4EALDH1A1TNIKEML4ALK | |
| SCHEMBL28891739 | 0.87 | SLC2A1 (0.39) | KDM4EALDH1A1EML4ALKHTR1D | |
| SCHEMBL28891628 | 0.85 | SLC2A1 (0.41) | TNIKEML4ALKCHEK1SLC2A1 | |
| SCHEMBL28891635 | 0.83 | SLC2A1 (0.41) | TNIKEML4ALKCHEK1SLC2A1 | |
| SCHEMBL29876463 | 0.77 | EML4 (0.47) | EML4ALKPIM1RETROS1 | |
| SCHEMBL28891852 | 0.77 | EML4 (0.47) | EML4ALKPIM1RETROS1 | |
| SCHEMBL28891629 | 0.73 | SLC2A1 (0.47) | TNIKEML4ALKCHEK1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197154-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |