Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | PARG | Q86W56 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23693187 | 1.00 | HPGD (0.53) | HPGDPOLBCTSLMMP12MMP13 | |
| SCHEMBL23693158 | 0.89 | POLB (0.42) | HPGDPOLBCTSLMMP12MMP13 | |
| SCHEMBL23693960 | 0.87 | POLB (0.42) | HPGDPOLBCTSLMMP12MMP13 | |
| SCHEMBL7065810 | 0.82 | SMN1; SMN2 (0.55) | HPGDMMP12MMP13SMN1; SMN2USP2 | |
| SCHEMBL6771108 | 0.79 | MMP1 (0.51) | MMP13SMN1; SMN2USP2HTTALDH1A1 | |
| SCHEMBL6417494 | 0.77 | MMP12 (0.56) | HPGDMMP12MMP13SMN1; SMN2USP2 | |
| Hydroxyamine SCHEMBL7578513 | 0.77 | HTT (0.53) | HPGDMMP12MMP13SMN1; SMN2USP2 | |
| SCHEMBL6772598 | 0.76 | HTT (0.55) | HPGDMMP12MMP13SMN1; SMN2USP2 | |
| SCHEMBL23673531 | 0.74 | CTSL (0.69) | CTSLMMP12MMP13CTSKCTSS | |
| SCHEMBL23693540 | 0.73 | CTSK (0.53) | CTSLMMP12MMP13CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981251-B | Dibenzofuran derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114981251-A | Diphenyl furan derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-08-30 | — | — | CN | disclosed |