Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 14/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 5/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 4/20 | 0.48 |
| ▸ | PLA2G5 | P39877 | 4/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | BPGM | P07738 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13248543 | 0.80 | DHODH (0.43) | ALDH1A1DHODHPDE10A | |
| SCHEMBL3000311 | 0.80 | ALOX5AP (0.52) | ALDH1A1PDE10A | |
| SCHEMBL2246698 | 0.79 | DHODH (0.41) | ALDH1A1DHODHPDE10A | |
| SCHEMBL2994400 | 0.78 | RAB9A (0.43) | ALDH1A1DHODH | |
| SCHEMBL2997210 | 0.77 | HPGD (0.42) | ALDH1A1DHODHPDE10A | |
| SCHEMBL13248546 | 0.77 | PARP10 (0.49) | ALDH1A1 | |
| SCHEMBL2993323 | 0.76 | PARP10 (0.43) | ALDH1A1 | |
| SCHEMBL3106370 | 0.76 | MAPT (0.48) | ALDH1A1 | |
| SCHEMBL2990118 | 0.76 | HPGDS (0.44) | ALDH1A1 | |
| SCHEMBL2991930 | 0.76 | ALDH1A1 (0.73) | ALDH1A1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| WO-2008156721-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | ALDH1A1 159/4885PLA2G2A 185/4885PLA2G10 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.