Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.54 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.52 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ASPH | Q12797 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | TET3 | O43151 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL6129699 | 0.97 | KDM4E (0.52) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| SCHEMBL70035 | 0.94 | KDM4E (0.59) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| SCHEMBL7767700 | 0.91 | KDM4E (0.56) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| Water SCHEMBL336347 | 0.91 | KDM4E (0.56) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| Hydrochloric Acid SCHEMBL11594387 | 0.91 | KDM4E (0.56) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| Water SCHEMBL28665454 | 0.91 | KDM4E (0.56) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| Iodide SCHEMBL6129698 | 0.86 | KDM4E (0.52) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| SCHEMBL17712841 | 0.83 | SIRT6 (0.64) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| SCHEMBL15305157 | 0.81 | KDM4E (0.48) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| SCHEMBL17725120 | 0.81 | KDM4E (0.48) | KDM4EHCAR2NAPRTP4HTMP4HA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679925-B1 | Light valve with low emissivity coating as electrode | RESEARCH FRONTIERS INC (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0679925-A1 | Light valve with low emissivity coating as electrode | RESEARCH FRONTIERS INCORPORATED (US) | 1995-11-02 | — | — | EP | disclosed |
| US-5325220-A | Light valve with low emissivity coating as electrode | RESEARCH FRONTIERS INCORPORATED (US) | 1994-06-28 | — | — | US | disclosed |