Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | METAP2 | P50579 | 1/20 | 0.60 |
| ▸ | METAP1 | P53582 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | GLS | O94925 | 6/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687548 | 0.82 | FFAR2 (0.74) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL29855979 | 0.81 | FFAR2 (0.72) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL19914376 | 0.80 | GLS (0.60) | SMN1; SMN2GLSPOLB | |
| SCHEMBL31207176 | 0.79 | FFAR2 (0.64) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2028409 | 0.76 | CA1 (0.69) | PKMRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL20392510 | 0.76 | GLS (0.69) | ALDH1A1L3MBTL1GLSPOLB | |
| SCHEMBL10574471 | 0.76 | POLB (0.71) | SMN1; SMN2LMNAPOLB | |
| SCHEMBL24101681 | 0.76 | PDE5A (0.70) | RAB9ANPC1SMN1; SMN2LMNAMETAP2 | |
| SCHEMBL1897970 | 0.75 | NPC1 (1.00) | ALDH1A1PKMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13694245 | 0.74 | MAPK8 (0.63) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160311-A | Bifunctional compound for EGFR degradation and application thereof | 北京康辰药业股份有限公司 | 2022-10-11 | — | — | CN | claimed |
| CN-115160311-A | Bifunctional compound for EGFR degradation and application thereof | 北京康辰药业股份有限公司 | 2022-10-11 | — | — | CN | disclosed |