SCHEMBL29918322

SCHEMBL29918322

O=C(O)c1ccccc1NS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC25A1 P53007 1/20 1.00
MEN1 O00255 4/20 0.68
KMT2A Q03164 4/20 0.68
LMNA P02545 1/20 0.68
DNMT1 P26358 3/20 0.64
DNMT3A Q9Y6K1 1/20 0.64
CASP6 P55212 4/20 0.62
SLC10A2 Q12908 1/20 0.61
SLC10A1 Q14973 1/20 0.61
SLC10A6 Q3KNW5 1/20 0.61
POLB P06746 2/20 0.60
KDM4E B2RXH2 2/20 0.60
TDP1 Q9NUW8 1/20 0.58
VCAM1 P19320 2/20 0.56
ACLY P53396 1/20 0.56
L3MBTL1 Q9Y468 4/20 0.56
APAF1 O14727 1/20 0.56
KDM4A O75164 1/20 0.56
DUSP3 P51452 1/20 0.56
PTPN5 P54829 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30000258 1.00 SLC25A1 (1.00) SLC25A1MEN1KMT2ALMNADNMT1
SCHEMBL5598171 1.00 SLC25A1 (1.00) SLC25A1MEN1KMT2ALMNADNMT1
SCHEMBL30777865 1.00 SLC25A1 (1.00) SLC25A1MEN1KMT2ALMNADNMT1
SCHEMBL10389335 0.86 SLC25A1 (0.75) SLC25A1MEN1KMT2ALMNADNMT1
SCHEMBL34475240 0.84 MEN1 (0.78) SLC25A1MEN1KMT2ALMNAPOLB
SCHEMBL27770307 0.84 MEN1 (0.78) SLC25A1MEN1KMT2ALMNAPOLB
SCHEMBL31404880 0.84 SLC25A1 (0.72) SLC25A1MEN1KMT2ALMNADNMT1
SCHEMBL13146602 0.82 SLC25A1 (0.69) SLC25A1KMT2ALMNADNMT1DNMT3A
SCHEMBL11749307 0.81 SLC25A1 (0.68) SLC25A1MEN1KMT2ALMNADNMT1
SCHEMBL10695037 0.81 MEN1 (0.73) SLC25A1MEN1KMT2ALMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119055773-A Drug for reversing drug resistance of EGFR-TKI of third generation lung cancer 华中农业大学 2024-12-03 CN claimed
US-20220323389-A1 TREATING NON-ALCOHOLIC FATTY LIVER DISEASE AND INFLAMMATORY STEATOHEPATITIS WITH SLC25A1 INHIBITORS GEORGETOWN UNIVERSITY (US) 2022-10-13 US claimed
CN-120757475-A Small molecule inhibitor CTP13 targeting SLC25A1 and application thereof 中国医科大学附属第一医院 2025-10-10 CN disclosed
CN-119055773-B Application of CTPI-2/Orlistat/Etomoxir in preparation of medicine for reversing EGFR-TKI octenib resistance of third generation lung cancer 华中农业大学 2025-06-06 CN disclosed
CN-119055773-B Application of CTPI-2/Orlistat/Etomoxir in preparation of medicine for reversing EGFR-TKI octenib resistance of third generation lung cancer 华中农业大学 2025-06-06 CN disclosed
CN-119205162-A Shaanxi coal price index calculation method 陕西煤炭交易中心有限公司 2024-12-27 CN disclosed
CN-119055773-A Drug for reversing drug resistance of EGFR-TKI of third generation lung cancer 华中农业大学 2024-12-03 CN disclosed
CN-119055773-A Drug for reversing drug resistance of EGFR-TKI of third generation lung cancer 华中农业大学 2024-12-03 CN disclosed
CN-116019811-B Application of GSK-J4 in preparation of medicine for resisting gram positive bacteria infection 华中科技大学协和深圳医院 2024-04-12 CN disclosed
WO-2023237873-A1 TARGETS FOR CANCER THERAPY THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) 2023-12-14 WO disclosed
EP-4181911-A1 THE ROLE OF PMCIC IN THE TUMOR MICROENVIRONMENT Universitätsklinikum Regensburg (DE) 2023-05-24 EP disclosed
CN-116019811-A Application of GSK-J4 in preparation of medicine for resisting gram positive bacteria infection 华中科技大学协和深圳医院 2023-04-28 CN disclosed
US-20220323389-A1 TREATING NON-ALCOHOLIC FATTY LIVER DISEASE AND INFLAMMATORY STEATOHEPATITIS WITH SLC25A1 INHIBITORS GEORGETOWN UNIVERSITY (US) 2022-10-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220323389-A1 TREATING NON-ALCOHOLIC FATTY LIVER DISEASE AND INFLAMMATORY STEATOHEPATITIS WITH SLC25A1 INHIBITORS SLC10A1, SLC27A1, SLC25A3 SLC25A1 16/4885MEN1 4426/4885KMT2A 2418/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.