Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.42 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.42 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174339 | 0.80 | TTK (0.52) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL29927534 | 0.78 | JAK2 (0.37) | PARP1DYRK3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL6174210 | 0.77 | JAK2 (0.56) | PARP1CLK4JAK2 | |
| SCHEMBL29927573 | 0.75 | DYRK3 (0.39) | SIRT2PARP1DYRK3MAP4K4PIM1 | |
| SCHEMBL6174664 | 0.74 | KCNA5 (0.49) | GRM5RPS6KB1 | |
| SCHEMBL18580116 | 0.70 | TLR8 (0.51) | IRAK4PARP1MAP4K4PIM1AURKB | |
| SCHEMBL2991676 | 0.70 | LMNA (0.57) | IRAK4PARP1MAP4K4PIM1RPS6KB1 | |
| SCHEMBL27964788 | 0.70 | RORB (0.68) | PARP1RPS6KB1RORBJAK2 | |
| SCHEMBL30108241 | 0.70 | CDC7 (0.53) | PARP1CLK4RORB | |
| SCHEMBL945856 | 0.69 | KDM4E (0.55) | PARP1CLK4RORBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197740-A1 | BIARYL AMIDE AND HETEROARYL AMIDES FOR TREATMENT OF CANDIDA ALBICANS INFECTION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-09-22 | — | — | WO | claimed |