Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536108 | 1.00 | PGR (0.43) | PGRMAPTTDP1NPSR1POLB | |
| SCHEMBL23535959 | 0.88 | SMN1; SMN2 (0.42) | MAPTTDP1NPSR1POLBALDH1A1 | |
| SCHEMBL29948492 | 0.88 | SMN1; SMN2 (0.42) | MAPTTDP1NPSR1POLBALDH1A1 | |
| SCHEMBL29948574 | 0.85 | POLB (0.42) | MAPTTDP1POLBALDH1A1KMT2A | |
| SCHEMBL23536112 | 0.85 | POLB (0.42) | MAPTTDP1POLBALDH1A1KMT2A | |
| SCHEMBL28867404 | 0.81 | LMNA (0.39) | MAPTNPSR1POLBLMNATP53 | |
| SCHEMBL29931877 | 0.80 | CA2 (0.43) | POLBDRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL23555180 | 0.78 | OPRL1 (0.38) | MAPTTDP1POLBALDH1A1KMT2A | |
| SCHEMBL23536165 | 0.77 | TSHR (0.43) | MAPTNPSR1POLBALDH1A1KMT2A | |
| SCHEMBL29931966 | 0.77 | TSHR (0.43) | MAPTNPSR1POLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |