Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536204 | 1.00 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1USP2ALOX15OPRK1 | |
| SCHEMBL23555092 | 0.90 | MCOLN2 (0.36) | L3MBTL1LMNAKDM4EMAPTPOLB | |
| SCHEMBL29932095 | 0.90 | LMNA (0.40) | ALDH1A1L3MBTL1LMNAKDM4EMAPT | |
| SCHEMBL28867394 | 0.90 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1LMNAKDM4EPOLB | |
| SCHEMBL29932066 | 0.90 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1LMNAKDM4EPOLB | |
| SCHEMBL28867429 | 0.89 | MCOLN2 (0.34) | ALDH1A1L3MBTL1LMNAKDM4EPOLB | |
| SCHEMBL23536230 | 0.88 | MCOLN2 (0.39) | ALDH1A1L3MBTL1HTTLMNAKDM4E | |
| SCHEMBL23536479 | 0.88 | MCOLN2 (0.48) | ALDH1A1L3MBTL1HTTLMNAKDM4E | |
| SCHEMBL23536384 | 0.86 | CRHBP (0.34) | ALDH1A1LMNAKMT2AMCOLN2HTR1A | |
| SCHEMBL23555120 | 0.86 | MCOLN2 (0.37) | L3MBTL1POLBKMT2AMEN1MCOLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |