Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 3/20 | 0.64 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187434 | 1.00 | TDO2 (0.64) | TDO2CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL7844961 | 0.86 | CYP2A6 (0.57) | TDO2CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL29935857 | 0.85 | CAPN1 (0.59) | TDO2CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL208051 | 0.85 | CAPN1 (0.59) | TDO2CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL15331451 | 0.82 | CYP2A6 (0.53) | TDO2CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL9377060 | 0.79 | CYP2A6 (0.66) | TDO2CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL29956305 | 0.79 | CYP2A6 (0.66) | TDO2CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL19178919 | 0.78 | TDO2 (1.00) | TDO2KDM4EALDH1A1MAPTGPR84 | |
| SCHEMBL639590 | 0.78 | CYP2A6 (0.64) | TDO2CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL1049957 | 0.78 | PIM3 (0.65) | TDO2CYP2A6KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577243-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2026-03-17 | — | — | US | disclosed |
| WO-2025060786-A1 | SIX-MEMBERED AND FIVE-MEMBERED FUSED RING DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 湘北威尔曼制药股份有限公司 | 2025-03-27 | — | — | WO | disclosed |
| EP-4313985-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE | Equinorm Ltd (FI) | 2024-02-07 | — | — | EP | disclosed |
| US-11820766-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-21 | — | — | US | disclosed |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-11 | — | — | US | disclosed |
| US-20220389002-A1 | Chiral Indole Compounds and Their Use | ARIAGEN, INC. (US) | 2022-12-08 | — | — | US | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-20220332713-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-10-20 | — | — | US | disclosed |
| WO-2022207979-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE | EQUINORM LTD (FI) | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220332713-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | TDO2 3858/4885CYP2A6 747/4885KDM4E 2437/4885 |
| US-12577243-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, FAAH | TDO2 1247/4885CYP2A6 555/4885KDM4E 3565/4885 |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | TDO2 3858/4885CYP2A6 747/4885KDM4E 2437/4885 |
| US-20220389002-A1 | Chiral Indole Compounds and Their Use | IDO1, IDO2, INMT | TDO2 27/4885CYP2A6 1229/4885KDM4E 1410/4885 |
| US-11820766-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | TDO2 3858/4885CYP2A6 747/4885KDM4E 2437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.