Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | CA9 | Q16790 | 3/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL17456631 | 0.95 | CA2 (0.59) | CA2CA9CA1PTGS2GAA | |
| SCHEMBL31318252 | 0.95 | CA2 (0.59) | CA2CA9CA1PTGS2GAA | |
| SCHEMBL29205864 | 0.95 | CA2 (0.59) | CA2CA9CA1PTGS2GAA | |
| Potassium Ion SCHEMBL28961756 | 0.83 | CA2 (0.55) | CA2CA9CA1GAASMN1; SMN2 | |
| Potassium Ion SCHEMBL31649258 | 0.82 | CA1 (0.59) | CA2CA9CA1PTGS2GAA | |
| Tetramethylammonium Ion SCHEMBL4624325 | 0.81 | PTGS2 (0.48) | CA2CA9CA1PTGS2 | |
| Potassium Ion SCHEMBL31649361 | 0.80 | PTGS2 (0.49) | CA2CA9PTGS2ENPP2 | |
| SCHEMBL27577633 | 0.78 | CA2 (0.55) | CA2CA9CA1GAASMN1; SMN2 | |
| SCHEMBL936809 | 0.78 | CA2 (0.67) | CA2CA9CA1GAASMN1; SMN2 | |
| SCHEMBL31318248 | 0.77 | CA1 (0.59) | CA2CA9CA1PTGS2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122031506-A | Chiral control | 波涛生命科学有限公司 | 2026-05-15 | — | — | CN | disclosed |
| US-20250360434-A1 | METAL-ORGANIC FRAMEWORKS FOR THE REMOVAL OF UREMIC TOXINS | UNIV NORTHWESTERN (US) | 2025-11-27 | — | — | US | disclosed |
| US-12403412-B2 | Metal-organic frameworks for the removal of uremic toxins | NORTHWESTERN UNIVERSITY (US) | 2025-09-02 | — | — | US | disclosed |
| WO-2024203772-A1 | METHOD FOR PRODUCING ALPHA-CYANOACRYLATE | 東亞合成株式会社 | 2024-10-03 | — | — | WO | disclosed |
| US-20230091848-A1 | DISEASE DETECTION AND TREATMENT BASED ON PHENYLACETYL GLUTAMINE LEVELS | THE CLEVELAND CLINIC FOUNDATION | 2023-03-23 | — | — | US | disclosed |
| EP-4100541-A1 | DISEASE DETECTION AND TREATMENT BASED ON PHENYLACETYL GLUTAMINE LEVELS | The Cleveland Clinic Foundation (US) | 2022-12-14 | — | — | EP | disclosed |
| US-20220339601-A1 | METAL-ORGANIC FRAMEWORKS FOR p-Cresyl SULFATE ADSORPTION | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION | 2022-10-27 | — | — | US | disclosed |