Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ME2 | P23368 | 3/20 | 0.40 |
| ▸ | ME1 | P48163 | 3/20 | 0.40 |
| ▸ | ME3 | Q16798 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20639686 | 0.84 | GPR119 (0.48) | GAAMAPTHTTGPR119 | |
| SCHEMBL6174267 | 0.84 | GPR119 (0.48) | GAAMAPTALDH1A1HTTLMNA | |
| SCHEMBL14884466 | 0.84 | GPR119 (0.48) | GAAMAPTHTTLMNAGPR119 | |
| SCHEMBL3034991 | 0.83 | GPR119 (0.45) | MAPTALDH1A1HTTLMNAGPR119 | |
| SCHEMBL3117217 | 0.80 | MAPT (0.52) | GAAMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6174262 | 0.78 | ALDH1A1 (0.47) | GAAKDM4EMAPTALDH1A1HTT | |
| SCHEMBL7887520 | 0.77 | DRD4 (0.60) | KDM4EMAPTALDH1A1DRD4USP2 | |
| SCHEMBL3173639 | 0.77 | MAPT (0.61) | GAAKDM4EMAPTALDH1A1HTT | |
| SCHEMBL7341982 | 0.76 | MAPT (0.56) | MAPTALDH1A1HTTLMNAGPR119 | |
| SCHEMBL6174590 | 0.76 | RAB9A (0.53) | KDM4EMAPTALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545666-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2026-02-10 | — | — | US | disclosed |
| CN-115536602-A | Preparation method of posaconazole intermediate | 成都海博为药业有限公司 | 2022-12-30 | — | — | CN | disclosed |
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | GAA 1408/4885KDM4E 2405/4885MAPT 3556/4885 |
| US-12545666-B2 | Itraconazole analogs and use thereof | SHH, SMO, GLI1 | GAA 4299/4885KDM4E 3294/4885MAPT 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.