Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8718822 | 0.90 | HTT (0.50) | GPR119ALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL14884466 | 0.84 | GPR119 (0.48) | GPR119ADRB1GAADRD4AKR1C3 | |
| SCHEMBL20639686 | 0.84 | GPR119 (0.48) | GPR119GAAAKR1C3HTTMAPT | |
| SCHEMBL6174262 | 0.84 | ALDH1A1 (0.47) | GPR119ADRB1SIGMAR1ALDH1A1GAA | |
| SCHEMBL3034991 | 0.80 | GPR119 (0.45) | GPR119ALDH1A1GFERAKR1C3HTT | |
| SCHEMBL3117217 | 0.80 | MAPT (0.52) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL7887520 | 0.80 | DRD4 (0.60) | SIGMAR1ALDH1A1DRD4MAPT | |
| SCHEMBL15912908 | 0.75 | GPR119 (0.44) | GPR119ALDH1A1GAADRD4HTT | |
| SCHEMBL8931686 | 0.75 | CHRNB2 (0.52) | GPR119HTTMAPT | |
| SCHEMBL6175083 | 0.75 | ALDH1A1 (0.44) | ALDH1A1DRD4HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261330-A1 | Derivatives of 2,2,4-trisubstituted tetrahydrofuran an antifungal agents | RANBAXY LABORATORIES LIMITED (IN) | 2005-11-24 | — | — | US | disclosed |
| EP-1497298-A1 | DERIVATIVES OF 2,2,4-TRISUBSTITUTED TETRAHYDROFURAN AS ANTIFUNGAL AGENTS | RANBAXY LABORATORIES, LTD. (IN) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087106-A1 | DERIVATIVES OF 2,2,4-TRISUBSTITUTED TETRAHYDROFURAN AS ANTIFUNGAL AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261330-A1 | Derivatives of 2,2,4-trisubstituted tetrahydrofuran an antifungal agents | ERG28, DPM1, CYP51A1 | GPR119 1617/4885HTR3E 2657/4885HTR3B 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.