Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536252 | 0.79 | KDM4E (0.51) | SMN1; SMN2HPGDKDM4EALDH1A1NPSR1 | |
| SCHEMBL23536110 | 0.78 | SCD5 (0.38) | LMNASMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL20815419 | 0.74 | POLB (0.48) | LMNAPOLBSMN1; SMN2HPGDKDM4E | |
| SCHEMBL5456459 | 0.73 | LMNA (0.49) | LMNAPOLBSMN1; SMN2HPGDKDM4E | |
| SCHEMBL7339506 | 0.73 | LMNA (0.61) | LMNAPOLBSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL29491200 | 0.73 | ALDH1A1 (0.43) | LMNAPOLBSMN1; SMN2HPGDKDM4E | |
| SCHEMBL8922008 | 0.72 | CHRM4 (0.59) | LMNAPOLBSMN1; SMN2ALDH1A1CHRM2 | |
| SCHEMBL7449135 | 0.71 | POLB (0.63) | LMNAPOLBSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL15208260 | 0.70 | CACNA1B (0.43) | LMNAPOLBSMN1; SMN2HPGDKDM4E | |
| SCHEMBL29997884 | 0.70 | LMNA (0.43) | LMNAPOLBSMN1; SMN2PLA2G2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |