Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 6/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1874207 | 1.00 | TRPV4 (0.49) | TRPV4KEAP1NFE2L2L3MBTL1OPRD1 | |
| SCHEMBL2804046 | 0.87 | L3MBTL1 (0.45) | TRPV4L3MBTL1OPRD1PKMCA2 | |
| SCHEMBL31235134 | 0.82 | CA2 (0.51) | KEAP1NFE2L2L3MBTL1PKMCA2 | |
| SCHEMBL16936936 | 0.82 | CA2 (0.51) | KEAP1NFE2L2L3MBTL1PKMCA2 | |
| SCHEMBL29482639 | 0.81 | TRPV4 (0.68) | TRPV4L3MBTL1GAACA2CA12 | |
| SCHEMBL1817972 | 0.81 | TRPV4 (0.53) | TRPV4L3MBTL1PKMSMN1; SMN2CA2 | |
| SCHEMBL1817970 | 0.81 | PKM (0.55) | TRPV4L3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL74997 | 0.81 | TRPV4 (0.68) | TRPV4L3MBTL1GAACA2CA12 | |
| SCHEMBL27724224 | 0.81 | KEAP1 (0.47) | KEAP1NFE2L2L3MBTL1OPRD1PKM | |
| SCHEMBL1817484 | 0.79 | TRPV4 (0.47) | TRPV4L3MBTL1PKMSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024243025-A1 | NAPHTHYL-SUBSTITUTED PYRIDO[4,3-D]PYRIMIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2024-11-28 | — | — | WO | disclosed |
| EP-4061124-A1 | TRPV4 RECEPTOR LIGANDS | University of Utah Research Foundation (US) | 2022-09-28 | — | — | EP | disclosed |