Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924103 | 0.89 | CYP19A1 (0.40) | CYP19A1MAOBFFAR1NR1H4 | |
| SCHEMBL2246114 | 0.86 | FFAR1 (0.49) | CYP19A1MAOBFFAR1ALDH1A1 | |
| SCHEMBL3000768 | 0.80 | MAOB (0.43) | CYP19A1MAOBFFAR1NR1H4ALDH1A1 | |
| SCHEMBL3626112 | 0.80 | MAOB (0.49) | CYP19A1MAOBFFAR1RAB9ACYP3A4 | |
| SCHEMBL30509596 | 0.77 | KIF11 (0.47) | CYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL9924105 | 0.77 | FFAR1 (0.46) | CYP19A1MAOBFFAR1ALDH1A1 | |
| SCHEMBL13248362 | 0.76 | KDM4E (0.53) | ALDH1A1RAB9ACYP3A4 | |
| SCHEMBL2795215 | 0.75 | CYP11B1 (0.43) | CYP19A1MAOBFFAR1ALDH1A1CYP3A4 | |
| SCHEMBL9924098 | 0.73 | ALOX5AP (0.48) | CYP19A1MAOBFFAR1NR1H4ALDH1A1 | |
| SCHEMBL24645112 | 0.73 | KDM4E (0.38) | CYP19A1MAOBFFAR1CYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| EP-2170065-A1 | DIPHENYL SUBSTITUTED ALKANES | Merck Sharp & Dohme Corp. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156721-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | CYP19A1 835/4885MAOB 1032/4885FFAR1 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.