Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11773659 | 0.77 | HSD17B10 (0.70) | AURKAHTTHSD17B10METAP2KCNH2 | |
| SCHEMBL2419692 | 0.76 | HTT (0.54) | AURKAHTTHSD17B10METAP2KCNH2 | |
| SCHEMBL10146396 | 0.76 | AURKA (0.58) | AURKAHTTHSD17B10METAP2KCNH2 | |
| SCHEMBL29951206 | 0.73 | NPBWR1 (0.54) | HSD17B10KCNH2DGAT1 | |
| SCHEMBL12353892 | 0.71 | CBFB (0.50) | HTTJUNNFKB1NFKB2RELA | |
| SCHEMBL23782321 | 0.70 | NPBWR1 (0.40) | METAP2KCNH2DGAT1KDM4EKMT2A | |
| SCHEMBL26039481 | 0.70 | IDO1 (0.47) | AURKAHTTHSD17B10METAP2KCNH2 | |
| SCHEMBL2004991 | 0.68 | METAP2 (0.44) | METAP2 | |
| SCHEMBL22481479 | 0.66 | DGAT1 (0.43) | AURKAKCNH2DGAT1 | |
| SCHEMBL10719652 | 0.66 | AURKA (0.41) | AURKAHTTHSD17B10METAP2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |